Intravoxel incoherent motion diffusion-weighted imaging for monitoring chemotherapeutic efficacy in gastric cancer

Table 1 Summary of the apparent diffusion coefficient and intravoxel incoherent motion parameters at baseline (day 0) and on days 1, 3, 5, and 7 in each groups (n = 5 per group)

	ADC (10-3 mm2/s)	IVIM parameters
		D (10-3 mm2/s)	f (%)	D* (mm2/s)
Control group
Day 0	0.514 ± 0.050	0.480 ± 0.049	32.424 ± 6.647	0.112 ± 0.017
Day 1	0.520 ± 0.056	0.497 ± 0.052	33.010 ± 7.121	0.114 ± 0.016
Day 3	0.537 ± 0.029	0.506 ± 0.025	33.606 ± 8.113	0.115 ± 0.020
Day 5	0.545 ± 0.047	0.504 ± 0.021	32.602 ± 6.684	0.117 ± 0.018
Day 7	0.561 ± 0.053	0.524 ± 0.064	35.100 ± 7.858	0.120 ± 0.016
1-d treatment group
Day 0	0.555 ± 0.028	0.524 ± 0.028	34.076 ± 7.247	0.171 ± 0.049
Day 1	0.597 ± 0.064	0.612 ± 0.065	21.912 ± 5.032	0.115 ± 0.040
3-d treatment group
Day 0	0.528 ± 0.012	0.510 ± 0.019	37.066 ± 7.331	0.147 ± 0.025
Day 3	0.686 ± 0.107	0.636 ± 0.121	18.596 ± 5.766	0.083 ± 0.029
5-d treatment group
Day 0	0.594 ± 0.069	0.567 ± 0.065	34.664 ± 8.337	0.173 ± 0.068
Day 5	0.804 ± 0.136	0.777 ± 0.107	17.344 ± 4.352	0.070 ± 0.045
7-d treatment group
Day 0	0.560 ± 0.060	0.535 ± 0.081	37.598 ± 5.852	0.148 ± 0.082
Day 7	0.823 ± 0.221	0.710 ± 0.236	20.040 ± 3.042	0.065 ± 0.018

ADC: Apparent diffusion coefficient; IVIM: Intravoxel incoherent motion.

Table 2 Correlation between apparent diffusion coefficient and intravoxel incoherent motion parameters, microvessel density, cellular apoptosis and necrosis fraction of tumors (n = 25)

	NF (%)		MVD (vessels/HPF)		Apoptosis (%)
	rs	P value	rs	P value	rs	P value
ADC (× 10-3 mm2/s)	0.720	< 0.001	-0.395	0.051	0.626	0.001
IVIM parameters
D (× 10-3 mm2/s)	0.522	0.007	-0.201	0.335	0.542	0.005
f (%)	-0.347	0.089	0.618	0.001	-0.550	0.004
D* (× mm2/s)	-0.378	0.062	0.538	0.006	-0.692	< 0.001

P < 0.05 is considered to be statistically significant. ADC: Apparent diffusion coefficient; IVIM: Intravoxel incoherent motion; MVD: Microvessel density; NF: Necrosis fraction.