Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2016; 22(24): 5520-5531
Published online Jun 28, 2016. doi: 10.3748/wjg.v22.i24.5520
Intravoxel incoherent motion diffusion-weighted imaging for monitoring chemotherapeutic efficacy in gastric cancer
Xiao-Li Song, Heoung Keun Kang, Gwang Woo Jeong, Kyu Youn Ahn, Yong Yeon Jeong, Yang Joon Kang, Hye Jung Cho, Chung Man Moon
Xiao-Li Song, Heoung Keun Kang, Yong Yeon Jeong, Yang Joon Kang, Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do 519-763, South Korea
Gwang Woo Jeong, Chung Man Moon, Department of Radiology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju 501-757, South Korea
Kyu Youn Ahn, Hye Jung Cho, Department of Anatomy, Chonnam National University Medical School, Gwangju 501-746, South Korea
Author contributions: Song XL and Jeong YY designed the studies; Song XL, Kang YJ and Moon CM performed the majority of experiments; Song XL, Ahn KY, Kang YJ and Cho HJ contributed to the analysis and interpretation of imaging date and histological examination; Song XL wrote the first draft of the manuscript; Jeong GW and Kang HK have approved the final manuscript and completed manuscript; Also, all authors agree with the content of the manuscript.
Supported by National Research Foundation of South Korea, No. NRF-2013R1A1A2013878 and No. 2015R1A2A2A01007827.
Institutional animal care and use committee statement: All procedures involved animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Chonnam National University [CNU IACUC-H-2015-41].
Conflict-of-interest statement: The authors declared that they have no conflicts of interest to this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Heoung Keun Kang, MD, Professor of Medicine, Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do 519-763, South Korea. hkkang@jnu.ac.kr
Telephone: +82-61-3797101 Fax: +82-61-3797133
Received: February 24, 2016
Peer-review started: February 25, 2016
First decision: March 31, 2016
Revised: April 12, 2016
Accepted: April 20, 2016
Article in press: April 20, 2016
Published online: June 28, 2016
Processing time: 118 Days and 3.5 Hours
Core Tip

Core tip: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) is useful for monitoring changes of molecular diffusion and microcirculation in gastric cancer at the early stage of chemotherapy. The apparent diffusion coefficient (ADC) and IVIM parameters of true water molecular diffusion coefficient (D) could be reliable marker to detect the necrosis and cellular apoptosis, while perfusion-related IVIM parameters of perfusion fraction (f) and pseudo-related diffusion coefficient (D*) are capable of noninvasive assessment of angiogenesis activity in gastric cancer undergoing chemotherapy.