Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature

Table 1 Clinicopathological features of lymphoepithelioma-like hepatocellular carcinoma reported in the literature until 2015

Case (ref.)	Age (yr)	Sex/Race	Multifocal	Tumor size (cm)	HBV	HCV	EBV	Cirrhosis	AFP	Preoperative therapy	Postoperative therapy	Outcome
1 (18)	50	M/W	No	4	+	+	-	+	N	None	None	Alive w/o recurrence (10 yr)
2 (18)	54	M/W	Yes	2	-	-	-	-	N	Chemo-emb	None	DOD (7.7 yr)
3 (18)	59	M/W	Yes	5	+	+	-	+	N	None	Adj chemo	Alive w/o recurrence (8 yr)
4 (18)	45	M/W	No	2	-	+	-	+	N	None	Adj chemo	Alive w/o recurrence (4.7 yr)
5 (18)	64	M/W	Yes	4	-	-	-	+	N	Chemo-emb	Adj chemo	Alive w/o recurrence (3 yr)
6 (20)	39	F/H	No	1	-	+	+	+	-	None	None	DOD (5 mo)
7 (21)	56	M/?	No	3	-	+	-	+	N	None	Chemo for recurrence	DOD (21 mo)
8 (22)	47	F/?	No	2.2	-	-	-	-	-	None	Not describe	Alive w/o recurrence (15 mo)
9 (2)	57	M/?	No	2.7	+	-	-	+	E	None	Not describe	Alive w/o recurrence (50 mo)
10 (19)	79	M/A	No	5	-	-	-	-	E	None	Chemo for recurrence	Alive with recurrence (20 mo)
11 (17)	74	F/W	Yes	6.5	-	-	-	-	N	None	Not describe	DOD
12 (17)	65	M/W	No	4.8	-	-	-	-	N	None	Not describe	Died of unrelated cause
13 (17)	65	F/W	No	1.3	-	-	-	-	E	None	Not describe	Alive w/o recurrence
14 (17)	70	F/W	No	2.7	-	-	-	-	E	None	Not describe	Alive w/o recurrence
15 (17)	61	F/W	Yes	9.5	-	-	-	-	N	None	Not describe	Died of unrelated cause
16 (17)	78	M/W	No	10.5	-	-	-	-	N	None	Not describe	Alive with recurrence
17 (17)	78	F/W	No	6	-	-	-	-	N	None	Not describe	Alive w/o recurrence
18 (17)	57	F/W	No	13	-	-	-	-	N	Yes (unknown)	Not describe	Died of unrelated cause
19 (present case)	81	F/W	No	7.2	-	+	-	-	E	None	None	Alive w/o recurrence (15 mo)

Table 2 Clinicopathological features of lymphoepithelioma-like hepatocellular carcinoma reported by Chan et al[23] in March 2015 in their 9-year retrospective study

No. of cases	Age (mean)	Sex (M/F)	Multifocal	Tumor size (mean, cm)	HBV	HCV	EBV	Cirrhosis	AFP (> 20 mg/L)	Outcome (5-yr survival)
20	57.5	13/7	-	3.8	17	-	-	8	13	94.1%

HBV: Hepatitis B virus; HCV: Hepatitis C virus; EBV: Epstein-Barr virus; AFP: Alpha-fetoprotein; N: Normal; E: Elevated.