Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2015; 21(36): 10468-10474
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10468
Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature
Andrea Cacciato Insilla, Pinuccia Faviana, Luca Emanuele Pollina, Paolo De Simone, Laura Coletti, Franco Filipponi, Daniela Campani
Andrea Cacciato Insilla, Pinuccia Faviana, Luca Emanuele Pollina, Daniela Campani, Department of Surgical, Medical, Molecular Pathology and Critical Area, Division of Surgical Pathology, University Hospital of Pisa, 56124 Pisa, Italy
Paolo De Simone, Laura Coletti, Franco Filipponi, Department of Surgical, Medical, Molecular Pathology and Critical Area, Division of Liver Surgery and Transplantation, University Hospital of Pisa, 56124 Pisa, Italy
Author contributions: Cacciato Insilla A and Campani D contributed equally to this work and reported the case; Coletti L researched the bibliography; Cacciato Insilla A and Campani D wrote the paper; Faviana P and Pollina LE contributed to the histopathological diagnosis; and De Simone P and Filipponi F provided clinical information and approved the submission of the paper.
Supported by University of Pisa funds.
Institutional review board statement: For case report, the Italian legislation requires patients have to consent to diffusion of personal data and health records. No further authorization is required nor approval from Local Ethics Committee.
Informed consent statement: The patient participant to the study provided informed written consent.
Conflict-of-interest statement: Daniela Campani has not received fees for serving as a speaker, a consultant or an advisory board member for any organizations.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Daniela Campani, MD, Professor of Pathology, Department of Surgical, Medical, Molecular Pathology and Critical Area, Division of Surgical Pathology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy. daniela.campani@med.unipi.it
Telephone: +39-50-995690 Fax: +39-50-996891
Received: February 13, 2015
Peer-review started: February 22, 2015
First decision: April 23, 2015
Revised: May 29, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: September 28, 2015
Processing time: 226 Days and 19.7 Hours
Core Tip

Core tip: Here a case of Lymphoepithelioma-like hepatocellular carcinoma (HCC) described in a 81-year-old woman with a chronic hepatitis C infection. An ultrasound examination revealed a nodular lesion in the third segment of the liver, diagnosed as HCC after a needle biopsy. The patient underwent surgery with a liver segmentectomy. Histology of the removed specimen showed a poorly differentiated HCC with a significant lymphoid stroma. Here we describe the clinico-pathological features of our case with a review of the few cases reported in literature.