Preoperative high level of D-dimers predicts unresectability of pancreatic head cancer

Table 1 Plasma peripheral, portal, bile and urinary D-dimer levels of resectable and unresectable pancreatic adenocarcinoma

Samples	Resectable (n = 29)		Unresectable (n = 35)		P value
	mean ± SD	Median	mean ± SD	Median
Peripheral blood D-dimer level (μg/L)	630.9 ± 593.8	476.1	1726.4 ± 2283.9	1009.3	< 0.001
Bile D-dimer level (μg/L)	2385.6 ± 3206	750	2745.6 ± 3697.7	870.2	0.947
Urine D-dimer level (μg/L)	154.5 ± 343.6	80.4	86.8 ± 64.9	55.7	0.398
Portal blood D-dimer level (μg/L)	2856.9 ± 3699.5	726.5	4106.9 ± 3965.1	2243.5	0.035

Table 2 Sensitivity and specificity and receiver operating characteristics analysis of D-dimer levels in all studied samples

Sample	ROC curve area	Standard error	Optimal operating point	Sensitivity	Specificity
Peripheral blood	0.78	0.05	570	82.6%	66.6%
Portal blood	0.65	0.07	604	44.8%	85.7%
Bile	0.50	0.08	810	60.7%	56.5%
Urine	0.43	0.08	130	17.8%	91.3%

ROC: Receiver operating characteristic.