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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 28, 2014; 20(32): 11199-11209
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11199
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11199
miRNA | Biopsies | FNA | Circulating | Ref. |
Let-7a | X (↓) | X (↓) | [33] | |
miR-34a | X (↓) | [24] | ||
miR-96 | X (↓) | [23] | ||
miR-99a | X (↑) | [55] | ||
miR-101 | X (↑) | [67] | ||
miR-132 | X (↑/↓) | [21,22] | ||
miR-141 | X (↓) | [27] | ||
miR-143 | X (↑) | [27] | ||
miR-145 | X (↑) | [27] | ||
miR-146a | X (↑) | [27] | ||
miR-148a | X (↓) | [27,29] | ||
miR-148b | X (↓) | X (↓) | [27,34] | |
miR-150 | X (↑) | [27] | ||
miR155 | X (↑) | X (↑) | [26,27,53,62,67,68] | |
miR-16 | X (↑) | [57] | ||
miR-181a | X (↑) | [26] | ||
miR-181b | X (↑) | [26] | ||
miR-181d | X (↑) | [26] | ||
miR-185 | X (↑) | [59] | ||
miR-191 | X (↑) | [55,59] | ||
miR-196a | X (↑) | X (↑) | X (↑) | [27,29,32,53,57] |
miR-196b | X (↑) | [27,29] | ||
miR-20a | X (↑) | [55,59] | ||
miR-200a | X (↑) | [56] | ||
miR-200b | X (↑) | [56] | ||
miR-203 | X (↑) | [28] | ||
miR-210 | X (↑) | X (↑) | [29,54] | |
miR-212 | X (↑) | [20] | ||
miR-216 | X (↓) | [27] | ||
miR-217 | X (↓) | X (↓) | [27,31] | |
miR-21 | X (↑) | X (↑) | X (↑) | [20,26,25,51,53,55,60,64,67-69] |
miR-210 | X (↑) | X (↑) | [27,53] | |
miR-221 | X (↑) | X (↑) | [20,26,58,69] | |
miR-222 | X (↑) | [20,26,27] | ||
miR-223 | X (↑) | [27] | ||
miR-24 | X (↑) | [55] | ||
miR-27a-3p | X (↑) | [59] | ||
miR-29c | X (↓) | [27] | ||
miR-30a-3p | X (↓) | [27] | ||
miR-301 | X (↑) | [20] | ||
miR-31 | X (↑) | [27] | ||
miR-375 | X (↓) | [27] | ||
miR-376a | X (↑) | [20] | ||
miR-494 | X (↓) | [27] | ||
miR-1290 | X (↑) | [61] |
miRNA | Biopsies | FNA | Prognostic | Predictive of treatment efficacy | Ref. |
miR-105, miR-127, miR-187, miR-30a-3p, miR-452, miR-518a-2 | X (↑) | + | [26] | ||
miR-155, miR-200, miR-203, miR-205 | X (↑) | + | [35] | ||
miR-21 (↑), miR-34a (↓), miR-30d (↓) | X | - | [37] | ||
miR-212 (↑), miR-675 (↑), miR-148a (↓), miR-187 (↓), let-7g (↓) | X | - | [38] | ||
miR-146 (↑), miR-205 (↓), miR-7 (↓) | X | - | - | [50] | |
miR-10b | X (↑) | - | [51,52] | ||
miR-196a | X (↑) | - | [26] | ||
miR-219 | X (↑) | - | [36] | ||
miR-200c | X (↑) | + | [36] | ||
miR-21 | X (↑) | X (↑) | - | - | [40,41,51] |
miRNA | Expression | Known target(s) | Function | Ref. |
Let-7 | ↓ | KRAS | Inhibition of cell proliferation, chemosensitization | [33,85,86] |
miR-10b | ↑ | TIP30 | Increased cell proliferation and invasion | [52] |
miR-21 | ↑ | Inhibition of cell proliferation, invasion, tumor growth, chemoresistance and inhibition of apoptosis | [95] | |
miR-23b | Radioresistance | [91] | ||
miR-29a | Wnt/β-catenin | Chemosensitization to gemcitabine | [88] | |
miR-34a | ↓ | Smad3 | Inhibition of cell proliferation and invasion, induction of apoptosis | [82,83,94] |
miR-96 | ↓ | KRAS | Inhibition of cell proliferation, invasion, tumor growth and induction of apoptosis | [23,70] |
miR-99b | mTOR | Radioresistance | [90] | |
miR-132 | ↑↓ | Rb1 | Alteration of cell proliferation | [31,32] |
miR-138 | lipocalin | Inhibition of tumorigenicity | [93] | |
miR-141 | ↓ | MAP4K4 | Inhibition of cell proliferation and invasion, chemosensitization | [92] |
miR-142-3p | Inhibition of cell proliferation | [72] | ||
miR-148a | ↓ | None | [78] | |
miR-148b | ↓ | AMPKα1 | Inhibition of cell proliferation, invasion and chemosensitization | [79] |
miR-150* | IGF-1R | Induction of apoptosis | [73] | |
miR-181b | ↑ | NFkB | Chemosensitization to gemcitabine | [89] |
miR-197 | Induction of EMT | [75] | ||
miR-198 | ↓ | MSLN, OCT-2, PBX-1, VCP | Inhibition of cell proliferation, invasion, tumor growth and induction of apoptosis | [71] |
miR-212 | ↑ | Rb1 | Increased cell proliferation | [21] |
miR-218 | ↓ | Inhibition of cell proliferation and tumor growth and metastasis | [84] | |
miR-221 | ↑ | Increased migration, proliferation and EMT | [77] | |
miR-320c | SMARCC1 | Chemosensitization to gemcitabine | [77] | |
miR-373 | Increased tumor growth | [74] | ||
miR-630 | IGF-1R | Induction of apoptosis | [73] | |
miR-655 | Inhibition of EMT | [76] |
- Citation: Gayral M, Jo S, Hanoun N, Vignolle-Vidoni A, Lulka H, Delpu Y, Meulle A, Dufresne M, Humeau M, Rieu MCD, Bournet B, Sèlves J, Guimbaud R, Carrère N, Buscail L, Torrisani J, Cordelier P. MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer. World J Gastroenterol 2014; 20(32): 11199-11209
- URL: https://www.wjgnet.com/1007-9327/full/v20/i32/11199.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i32.11199