Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis B virus infection

Table 1 Genotype and allele distributions of interleukin-6 tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and those with self- limiting hepatitis B virus infection n (%)

IL-6 SNP site	Chronic HBV infection	Self-limiting HBV infection	P value	OR (95%CI)
rs17147230	n = 501	n = 301
AA	155 (0.309)	85 (0.282)		1.0
AT	241 (0.481)	155 (0.515)	0.348	0.853 (0.611-1.189)
TT	105 (0.210)	61 (0.203)	0.784	0.944 (0.625-1.425)
A	551 (0.550)	325 (0.540)	0.696	1.041 (0.850-1.276)
T	451 (0.450)	277 (0.460)
rs2066992
GG	45 (0.090)	20 (0.066)		1.0
GT	190 (0.379)	118 (0.392)	0.252	0.716 (0.403-1.271)
TT	266 (0.531)	163 (0.542)	0.261	0.725 (0.414-1.272)
G	280 (0.279)	158 (0.262)	0.460	1.090 (0.868-1.369)
T	722 (0.721)	444 (0.738)
rs2069837
AA	331 (0.661)	202 (0.671)		1.0
AG	151 (0.301)	86 (0.286)	0.670	1.072 (0.780-1.472)
GG	19 (0.038)	13 (0.043)	0.758	0.892 (0.431-1.845)
A	813 (0.811)	490 (0.814)	0.898	0.983 (0.759-1.274)
G	189 (0.189)	112 (0.186)
rs2069852
AA	208 (0.415)	138 (0.458)		1.0
AG	229 (0.457)	132 (0.439)	0.364	1.151 (0.850-1.559)
GG	64 (0.128)	31 (0.103)	0.198	1.370 (0.848-2.213)
A	645 (0.644)	408 (0.678)	0.165	0.859 (0.693-1.064)
G	357 (0.356)	194 (0.322)

IL-6: Interleukin-6; HBV: Hepatitis B virus; SNP: Single nucleotide polymorphism.

Table 2 Distribution of haplotypes of interleukin-6 tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and those with self-limiting hepatitis B virus infection

Haplotypes	Frequency (cases)	Frequency (controls)	χ2	P value	OR (95%CI)
ATAA	526.10 (0.525)	306.81 (0.510)	0.267	0.6051	1.056 (0.860-1.297)
TGAG	89.34 (0.089)	45.98 (0.076)	0.753	0.3854	1.179 (0.813-1.709)
TGGG	172.46 (0.172)	96.25 (0.160)	0.358	0.5494	1.087 (0.827-1.429)
TTAA	117.81 (0.118)	101.19 (0.168)	8.380	0.0038	0.655 (0.491-0.873)
TTAG	70.30 (0.070)	33.8 (0.056)	1.237	0.2660	1.272 (0.832-1.944)