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World J Gastroenterol. Oct 28, 2013; 19(40): 6888-6893
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6888
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6888
Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis B virus infection
Xiao-Miao Zhao, Qin Zhou, Xu Li, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Yu-Feng Gao, Department of Hepatopathy, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Fa-Ming Pan, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Zhao XM and Gao YF contributed equally to this work; Zhao XM and Gao YF wrote the manuscript; Zhao XM ,Gao YF and Zhou Q performed the majority of experiments; Gao YF designed the study; Pan FM did the data analysis; and Li X provided the financial support for this work.
Supported by Grants from the National Natural Science Foundation of China, No. 81072342
Correspondence to: Xu Li, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230032, Anhui Province, China. aaylixu@qq.com
Telephone: +86-551-2922912 Fax: +86-551-2922912
Received: August 5, 2013
Revised: September 6, 2013
Accepted: September 16, 2013
Published online: October 28, 2013
Processing time: 99 Days and 16.9 Hours
Revised: September 6, 2013
Accepted: September 16, 2013
Published online: October 28, 2013
Processing time: 99 Days and 16.9 Hours
Core Tip
Core tip: This study included a large number of subjects with a single ethnic background (Chinese). This would further add to the statistical power of the analysis and identify more single nucleotide polymorphisms. We selected self-limiting hepatitis B virus-infected subjects, but not unexposed subjects as controls, therefore, our results may be more reliable than other studies that recruited blood donors as controls. In addition, we included only antiviral-naive subjects.