Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis

Table 1 Characteristics of included prospective studies for urinary trypsinogen activation peptide as a predictor of severity of acute pancreatitis

Ref.	Year	Country	Sampling time after admission	Cut-off value (nmol/L)	Total (n)	Male/female (n)	Mild/severe (n)	Mean age: male/female (yr)	Etiology
Neoptolemos et al[32]	2000	Multicenter	On admission	35	172	87/85	137/35	52 (29-84)	Biliary 74, alcoholic 62, other 36
Liu et al[34]	2002	China	On admission	35	41	NA	29/12	NA	NA
Khan et al[33]	2002	United States	On admission	35	58	33/25	39/19	69 ± 19	Biliary 26, alcoholic 18, HTC 3, postoperative (including ERCP) 9, idiopathic 2
Lempinen et al[35]	2003	Finland	On admission	35	127	NA	98/29	NA	Biliary 24, alcoholic 74, other 29
Johnson et al[37]	2004	Multicenter	On admission	35	190	104/86	164/26	54 (42-70)	Biliary 70, alcohol 65, other 55
Huang et al[38]	2010	China	On admission	35	187	112/75	149/38	60.4 ± 6.7;	Biliary 139, alcoholic 19, other 29
								59.5 ± 8.1

ERCP: Endoscopic retrograde cholangiopancreatography; HTC: Hypercholesterolemic; NA: Not available.

Table 2 Diagnostic parameters of included studies

Ref.	Patients (n)	Patients analyzed (mild/severe)	TP	FP	FN	TN
Neoptolemos et al[32]	172	132 (105/27)	22	30	5	75
Liu et al[34]	41	41 (29/12)	11	3	1	26
Khan et al[33]	58	58 (39/19)	19	9	0	30
Lempinen et al[35]	127	118 (90/28)	18	16	10	74
Johnson et al[37]	190	190 (164/26)	12	33	14	131
Huang et al[38]	187	187 (149/38)	24	51	14	98

TP: True positive; FP: False positive; FN: False negative; TN: True negative.

Table 3 Meta-analysis outcomes of included studies

	Trials (n)	Patients (n)	AUC	DOR (95%CI)	Q	P value	I2
All studies	6	726	0.83	8.67 (3.70-20.33)	15.88	0.0072	68.50%
Study subgroups
Sample size ≥ 50	5	685	0.80	6.48 (3.05-13.74)	10.28	0.0360	61.10%
Single center	4	413	0.86	14.25 (3.39-59.80)	12.92	0.0048	76.80%
1992 Atlanta Classification	5	536	0.84	11.97 (4.17-34.36)	13.65	0.0085	70.70%

AUC: Area under the curve; DOR: Diagnostic odds ratios.