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World J Gastroenterol. Jul 28, 2013; 19(28): 4607-4615
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4607
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4607
Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis
Wei Huang, Tao Jin, Ping Xue, Qing Xia, Sichuan Provincial Pancreatitis Center, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Kiran Altaf, Li Wen, Muhammad A Javed, Marianne Johnstone, Christopher M Halloran, NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, University of Liverpool, Liverpool L69 3GA, United Kingdom
Jun-Jie Xiong, Department of Hepato-Biliary-Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Huang W and Altaf K contributed equally to this work; Xue P, Halloran CM and Xia Q designed the research, corrected and approved the manuscript; Huang W and Altaf K developed the literature search and carried out statistical analysis of the studies; Jin T, Xiong JJ, Wen L, Javed MA and Johnstone M performed data extraction; Huang W and Altaf K wrote the manuscript; and all authors read and approved the final manuscript.
Supported by Technology Supported Program of Sichuan Province, No. 2011SZ0291; the National Natural Science Foundation of China, No. 81072910; and National Institute for Health Research, United Kingdom
Correspondence to: Ping Xue, MD, PhD, Sichuan Provincial Pancreatitis Center, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Guoxue Rd 37, Chengdu 610041, Sichuan Province, China. sppc.wch.scu@gmail.com
Telephone: +86-28-85423373 Fax: +86-28-85423373
Received: March 16, 2013
Revised: May 20, 2013
Accepted: June 19, 2013
Published online: July 28, 2013
Processing time: 134 Days and 14.3 Hours
Revised: May 20, 2013
Accepted: June 19, 2013
Published online: July 28, 2013
Processing time: 134 Days and 14.3 Hours
Core Tip
Core tip: Currently, the assessment of acute pancreatitis severity on admission remains a challenge to clinicians. A single, rapid biochemical marker is the preferred choice than clinical and computed tomography scoring systems. In this study, the value of urinary trypsinogen activation peptide (uTAP), on admission, in predicting severity of acute pancreatitis was assessed. It was found that the ability of uTAP to predict severity of acute pancreatitis on admission was comparable to C-reactive protein (at 48 h) and was potentially better than the Acute Physiology and Chronic Health Evaluation II score (at 48 h), the most frequently used biochemical marker and clinical scoring system in acute pancreatitis, respectively.