Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels

Table 1 Demographic characteristics and laboratory values for the sample population and control group

	Controls (n = 22)	H. pylori infected (n = 70)	P value1	H. pylori eradicated (n = 52)	H. pylori non-eradicated (n = 18)	P value1
Sex, M/F	10/12	32/38	0.98	24/28	8/10	0.99
NW/OW	9/13	31/39	0.89	23/29	8/10	0.99
Age (yr)	40 ± 13	38 ± 12	0.30	38 ± 12	37 ± 11	0.74
Ghr initial, pg/mL	65 ± 19	64 ± 20	0.78	63 ± 20	64 ± 20	0.82
Ghr week 8, pg/mL	64 ± 17	58 ± 20	0.16	56 ± 20	62 ± 19	0.35
P value2	0.30	0.013a		0.012a	0.64
Ob initial, pg/mL	830 ± 296	771 ± 427	0.19	765 ± 461	787 ± 322	0.35
Ob week 8, pg/mL	818 ± 291	863 ± 462	0.70	914 ± 505	714 ± 269	0.22
P value2	0.65	0.07		0.01a	0.32
Ghr/Ob ratio initial	0.089	0.107	0.420	0.113	0.092	0.460
Ghr/Ob ratio week 8	0.092	0.086	0.480	0.081	0.099	0.140
P value2	1.0	0.06		0.01a	0.64
∆Ghr	-1.4	-5.9	0.49	-7.2	-2.0	0.19
∆Ob	-12.3	91.7	0.16	148.7	-72.8	0.02a
∆Ghr_%	4.5	-2.6	0.32	-3.9	0.9	0.16
∆Ob_%	-0.9	29.4	0.13	41.5	-5.3	0.03a

¹Mann-Whitney U test;

²Wilcoxon-signed ranks test.

^aP < 0.05 is significant. ∆: Change in mean; M: Male; F: Female; Ghr: Ghrelin; Ob: Obestatin; H. pylori: Helicobacter pylori; NW: Body mass index (BMI) ≤ 25 (normal weight); OW: BMI > 25 (overweight).

Table 2 Ghrelin and obestatin changes for normal weight and overweight patients after Helicobacter pylori eradication treatment

	Ghrelin initial, pg/mL	Ghrelin week 8, pg/mL	P value1	Obestatin initial, pg/mL	Obestatin week 8, pg/mL	P value1
H. pylori eradicated BMI-NW	58.8 ± 18.6	57.5 ± 22.0	0.46	759 ± 452	865 ± 456	0.08
H. pylori eradicated BMI-OW	68.8 ± 20.3	54.1 ± 17.1	0.002a	774 ± 413	975 ± 565	0.05a
P value2	0.07	0.67		0.17	0.62
H. pylori non-eradicated BMI-NW	68.7 ± 19.7	60.8 ± 22.0	0.57	780 ± 397	653 ± 258	0.20
H. pylori non-eradicated BMI-OW	69.0 ± 21.0	64.4 ± 15.6	0.88	796 ± 221	791 ± 280	0.77
P value2	0.40	0.69		0.76	0.46

¹Mann-Whitney U test;

²Wilcoxon-signed ranks test.

^aP < 0.05 is significant; BMI: Body mass index (NW: ≤ 25, normal weight; OW: > 25, overweight); H. pylori: Helicobacter pylori.