Ulasoglu C, Isbilen B, Doganay L, Ozen F, Kiziltas S, Tuncer I. Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels. World J Gastroenterol 2013; 19(15): 2388-2394 [PMID: 23613634 DOI: 10.3748/wjg.v19.i15.2388]
Corresponding Author of This Article
Dr. Celal Ulasoglu, Department of Gastroenterology, Istanbul Medeniyet University, Goztepe Education and Research Hospital, 34470 Istanbul, Turkey. ulasoglu@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Celal Ulasoglu, Levent Doganay, Safak Kiziltas, Ilyas Tuncer, Department of Gastroenterology, Istanbul Medeniyet University, Goztepe Education and Research Hospital, 34470 Istanbul, Turkey
Banu Isbilen, Department of Biochemistry, Istanbul Medeniyet University, Goztepe Education and Research Hospital, 34470 Istanbul, Turkey
Filiz Ozen, Medical Genetics, Istanbul Medeniyet University, Goztepe Education and Research Hospital, 34470 Istanbul, Turkey
Author contributions: Ulasoglu C designed the study, collected the materials and contributed to writing the manuscript; Kiziltas S and Tuncer I evaluated the data and contributed to writing the manuscript; Isbilen B and Ozen F performed laboratory procedures; Doganay L edited the manuscript and performed the statistical analysis.
Correspondence to: Dr. Celal Ulasoglu, Department of Gastroenterology, Istanbul Medeniyet University, Goztepe Education and Research Hospital, 34470 Istanbul, Turkey. ulasoglu@gmail.com
Telephone: +90-216-5666600 Fax: +90-216-5666628
Received: February 22, 2013 Revised: April 8, 2013 Accepted: April 9, 2013 Published online: April 21, 2013 Processing time: 56 Days and 6.4 Hours
Core Tip
Core tip: Ghrelin and obestatin are peptides that have opposing roles in the regulation of appetite and satiety. Helicobacter pylori (H. pylori), a common cause of gastric inflammation, may have important effects on these peptides and in turn be a potential target of anti-obesity strategies. While the interplay between H. pylori and these peptides are well studied, this study included two novel approaches. First, we collected serum samples at two separate time points for both the experimental and control groups, eliminating potential seasonal problems. Second, we focused on not only to H. pylori positive patients that responded to therapy, but also those who did not. This helped to distinguish the effects of antibiotherapy on ghrelin and obestatin regardless of the effectiveness of H. pylori treatment.
