Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion

Table 1 Claudin-1 expression and clinicopathologic characteristics of gastric carcinoma n (%)

	n	Expression in mucosa			Expression in invasive front
		Low	Over	P	Low	Over	P
Sex
Male	106	80 (75.5)	26 (24.5)	0.144	58 (54.7)	48 (45.3)	0.198
Female	30	27 (90)	3 (10)		21 (70)	9 (30)
Age
≤ 50	20	17 (85)	3 (15)	0.491	13 (65)	7 (35)	0.665
> 51	116	90 (77.6)	26 (22.4)		66 (56.9)	50 (43.1)
Histological type
Well-moderately differentiated	46	33 (71.7)	13 (28.3)	0.046	16 (34.8)	30 (65.2)	0.000
Poorly differentiated	65	57 (87.7)	8 (12.3)		48 (73.8)	17 (26.2)
Mucinous	25	17 (68)	8 (32)		15 (60)	10 (40)
Depth of invasion
Lamina propria or submucosa	18	17 (94.4)	1 (5.6)	0.099	16 (88.9)	2 (11.1)	0.007
Muscularis propria	28	19 (67.9)	9 (32.1)		18 (64.3)	10 (35.7)
Visceral peritoneum	90	71 (78.9)	19 (21.1)		45 (50)	45 (50)
Lymph node metastasis
Negative	52	46 (88.5)	6 (11.5)	0.048	38 (82.6)	14 (17.4)	0.009
Positive	84	61 (72.6)	23 (27.4)		41 (48.8)	43 (51.2)
Ki-67 index
I	20	17 (85)	3 (15)	0.529	14 (70)	6 (30)	0.389
II	57	43 (75.4)	14 (24.6)		33 (57.9)	24 (42.1)
III	54	42 (77.8)	12 (22.2)		28 (51.9)	26 (48.1)
IV	5	5 (100)	0		4 (80)	1 (20)

Table 2 Expression transformation of claudin-1 in gastric carcinomas

Expression in mucosa	Expression in invasive front	n
Low-expression	Low-expression (expression invariably)	79
Low-expression	Over-expression (expression variably)	28
Over-expression	Low-expression (expression variably)	0
Over-expression	Over-expression (expression invariably)	29

Table 3 Relation between the expression transformation of claudin-1 and biological behaviors of gastric carcinomas

	n	Low-expression in mucosa	Over-expression in invasive front
Histological type
Well-moderately differentiated	17	33	30
Poorly differentiated	9	57	17
Mucinous	2	17	10
Depth of invasion
Lamina propria or submucosa	1	17	2
Muscularis propria	1	19	10
Visceral peritoneum	26	71	45
Lymph node metastasis
Negative	8	46	14
Positive	20	61	43