Early diagnosis of bacterial and fungal infection in chronic cholestatic hepatitis B

Table 1 Comparison of serum bilirubin

Group	Case	Tbil (µmol/L)	DBil (µmol/L)	IBil (µmol/L)	DBil/TBil
A	38	220 ± 206	146 ± 136	73 ± 72	0.660 ± 0.078
B	23	59 ± 33b	22 ± 12d	38 ± 23	0.361 ± 0.105d
C	40	370 ± 227bf	214 ± 143bf	136 ± 92df	0.631 ± 0.840f

^bP < 0.01 vs group A; ^dP < 0.001 vs group A; ^fP < 0.001 vs group B.

Table 2 Comparison of TBA, ALP, DBil/ ALP and pulse rate (mean ± SE)

Group	n	TBA (µmol/L)	n	ALP (U/L)	n	DBil/ALP	n	Pulse rate (times/min)
A	22	148 ± 89	29	199 ± 68	29	0.78 ± 0.70	38	63.7 ± 6.4
B	16	31 ± 17d	18	149 ± 50a	18	0.14 ± 0.06b	23	78 ± 11d
C	22	140 ± 60f	34	156 ± 43ac	34	1.65 ± 1.05df	40	81 ± 12d

^aP < 0.05 vs group A;

^cP < 0.05 vs group B;

^bP < 0.01 vs group A;

^dP < 0.001 vs group A;

^fP < 0.001 vs group B.

Table 3 Tests of between-subjects effects (dependent variable: DBil/ALP)

Source	Type III sum of squares	Df	Mean square	F	P
Corrected model	50.025	2	25.012	129.672	<0.001
Infection	1.172	1	1.172	6.074	0.017
DBil	38.709	1	38.709	200.682	<0.001

Table 4 Pairwise comparisons (dependent variable: DBil/ALP)

Infection I	Infection J	Mean difference(I-J)	SE	P	95%	CI
1	2	-0.2931	0.119	0.017	-0.531	-0.055
2	1	0.2931	0.119	0.017	0.0551	0.531

¹The mean difference is significant at the 0.05 level.

Table 5 Logistic analysis of bacterial and fungal infection

	B	SE	Wald	Df	P	Exp (B)
Pulse rate	0.218	0.059	13.468	1	<0.001	1.244
DBil/ALP	1.064	0.447	5.657	1	0.017	2.899
Constant	-16.361	4.251	14.815	1	<0.001	<0.001

Table 6 Screening test of bacterial and fungal infection

Diagnosis		Sensitivity	Specificity	Diagnostic Index	AZ	Z	P
Pulse rat	≥ 80/min	0.625	1.000	1.625	0.889	20.372	<0.001
DBil/ALP	≥ 1.0	0.647	0.828	1.475	0.7373	4.022	<0.001