Early diagnosis of bacterial and fungal infection in chronic cholestatic hepatitis B

doi:10.3748/wjg.v10.i15.2228

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 15

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2051)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-6) series.

Item

Count

PDF

187

HTML

1449

Figures (1-3)

209

Tables (1-6)

206

Sum=2051

Aug 1, 2004 (publication date) through Nov 30, 2024

Times Cited of This Article

Times Cited (3)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Aug 1, 2004; 10(15): 2228-2231
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2228

Early diagnosis of bacterial and fungal infection in chronic cholestatic hepatitis B

Xiong-Zhi Wu, Dan Chen, Lian-San Zhao, Xiao-Hui Yu, Mei Wei, Yan Zhao, Qing Fang, Qian Xu

Xiong-Zhi Wu, Lian-San Zhao, Xiao-Hui Yu, Yan Zhao, Qing Fang, Qian Xu, Infectious Disease Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China

Dan Chen, Mei Wei, Luzhou Medical College, Luzhou 646000, Sichuan Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Xiong-Zhi Wu, Infectious Disease Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. ilwxz@163.com

Telephone: +86-28-85422650 Fax: +86-28-85423783

Received: January 2, 2004
Revised: January 3, 2004
Accepted: January 12, 2004
Published online: August 1, 2004

Abstract

AIM: To investigate the early diagnostic methods of bacterial and fungal infection in patients with chronic cholestatic hepatitis B.

METHODS: One hundred and one adult in -patients with chronic hepatitis B were studied and divided into 3 groups: direct bilirubin (DBil)/total bilirubin (TBil) ≥ 0.5, without bacterial and fungal infection (group A, n = 38); DBil/TBil < 0.5, without bacterial and fungal infection (group B, n = 23); DBil/TBil ≥ 0.5, with bacterial or fungal infection (group C, n = 40). The serum biochemical index and pulse rate were analyzed.

RESULTS: Level of TBil, DBil, alkaline phosphatase (ALP) and DBil/ALP in group A increased compared with that in group B. The level of ALP in group C decreased compared with that in group A, whereas the level of TBil, DBil and DBil/ALP increased (ALP: 156 ± 43, 199 ± 68, respectively, P < 0.05; TBil: 370 ± 227, 220 ± 206, respectively, P < 0.01; DBil: 214 ± 143, 146 ± 136, respectively, P < 0.01; DBil/ALP: 1.65 ± 1.05, 0.78 ± 0.70, respectively, P < 0.001). The level of DBil and infection affected DBil/ALP. Independent of the effect of DBil, infection caused DBil/ALP to rise (P < 0.05). The pulse rate in group A decreased compared with that in group B (63.7 ± 6.4, 77.7 ± 11.4, respectively, P < 0.001), and the pulse rate in group C increased compared with that in group A (81.2 ± 12.2, 63.7 ± 6.4, respectively, P < 0.001). The equation (infection = 0.218 pusle rate 1.064 DBil/ALP -16.361), with total accuracy of 85.5%, was obtained from stepwise logistic regression. Pulse rate (≥ 80/min) and DBil/ALP (≥ 1.0) were used to screen infection. The sensitivity was 62.5% and 64.7% respectively, and the specificity was 100% and 82.8% respectively.

CONCLUSION: Bacterial and fungal infection deteriorate jaundice and increase pulse rate, decrease serum ALP and increase DBil/ALP. Pulse rate, DBil/ALP and the equation (infection = 0.218 pusle rate + 1.064 DBil/ALP-16.361) are helpful to early diagnosis of bacterial and fungal infection in patients with chronic cholestatic hepatitis B.

Keywords: $[Keywords]