Combined expression of gastrointestinal hormone SP and anti-apoptosis gene Bcl-2 in gastric carcinoma

doi:10.3748/wjg.v6.iSuppl3.34

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 34-34
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.34

Combined expression of gastrointestinal hormone SP and anti-apoptosis gene Bcl-2 in gastric carcinoma

Yan-Ling Feng, Qin-Xian Zhang, Sheng-Lei Li

Yan-Ling Feng, Sheng-Lei Li, Department of Pathology Xinxiang Medical College, Xinxiang 453003, Henan Province, China

Qin-Xian Zhang, Department of Molecular Biology Henan Medical University, Zhengzhou 450052, Henan Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Yan-Ling Feng, Professor, Department of Pathology Xinxiang Medical College, Xin Yan Road, Xinxiang 453003, Henan Province, China. zhquy@371.net

Telephone: 373-3029347 (H), 3029123 (O)

Received: March 8, 2000
Revised: May 5, 2000
Accepted: May 25, 2000
Published online: September 15, 2000

Abstract

AIM: To study the combined expression of gastrointestinal hormone substance P and anti-apoptosis gene Bcl-2 in gastric carcinoma and its significance.

METHODS: Substance P and Bcl-2 protein expression was examined by the SP immunohistochemical method in 33 cases of gastric carcinoma, 17 adjacent the carcinoma and 13 normal gastric mucoma.

RESULTS: Positive expression of SP in gastric carcinoma was higher than that of both adjacent and normal mucosa (P < 0.001). There was no statistical difference in the positive expression between adjacent and normal mucosa (P > 0.05). The expression of Bcl-2 both in gastric carcinoma and adjacent tissues were higher than that of normal gastric mucosa (P < 0.05-0.01). But the positive expression of Bcl-2 had no statistical significance between gastric carcinoma and adjacent tissues.

CONCLUSION: Both gastrointestinal hormone SP and Bcl-2 gene have synergistic expression in gastric carcinoma, indicating that they all take par t in the occurrence of gastric carcinoma. Abnormal expression of Bcl-2 gene occurred in benign gastric pathological changes, once they become carcinoma, the positive expression of cell is no more increased, possibly because that there is no more increase of the intensity of Bcl-2 inhibition of cell apoptosis.

Key Words: Stomach neoplasms; Gastrointestinal hormones; Gastric mucosa; Substance P; Apoptosis; Immunohistochemistry

Citation: Feng YL, Zhang QX, Li SL. Combined expression of gastrointestinal hormone SP and anti-apoptosis gene Bcl-2 in gastric carcinoma. World J Gastroenterol 2000; 6(Suppl3): 34-34
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/34.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.34

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Website: www.wd.org.cn

E- Editor: Hu S