Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.34
Revised: May 5, 2000
Accepted: May 25, 2000
Published online: September 15, 2000
AIM: To study the combined expression of gastrointestinal hormone substance P and anti-apoptosis gene Bcl-2 in gastric carcinoma and its significance.
METHODS: Substance P and Bcl-2 protein expression was examined by the SP immunohistochemical method in 33 cases of gastric carcinoma, 17 adjacent the carcinoma and 13 normal gastric mucoma.
RESULTS: Positive expression of SP in gastric carcinoma was higher than that of both adjacent and normal mucosa (P < 0.001). There was no statistical difference in the positive expression between adjacent and normal mucosa (P > 0.05). The expression of Bcl-2 both in gastric carcinoma and adjacent tissues were higher than that of normal gastric mucosa (P < 0.05-0.01). But the positive expression of Bcl-2 had no statistical significance between gastric carcinoma and adjacent tissues.
CONCLUSION: Both gastrointestinal hormone SP and Bcl-2 gene have synergistic expression in gastric carcinoma, indicating that they all take par t in the occurrence of gastric carcinoma. Abnormal expression of Bcl-2 gene occurred in benign gastric pathological changes, once they become carcinoma, the positive expression of cell is no more increased, possibly because that there is no more increase of the intensity of Bcl-2 inhibition of cell apoptosis.