Clinical and pathological study on the hyperbaric oxygenation treatment of chronic hepatitis

doi:10.3748/wjg.v6.iSuppl3.132

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 132-132
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.132

Clinical and pathological study on the hyperbaric oxygenation treatment of chronic hepatitis

Wei Zhao, Wei Liu

Wei Zhao, Department of Medicine, Nanjing Second Hospital, Nanjing 210003, Jiangsu Province, China

Wei Liu, Department of Pathology, Nanjing Second Hospital, Nanjing 210003, Jiangsu Province, China

Author contributions: All authors contributed equally to the work.

Supported by The Youth Natural Scientific Foundation of Nanjing, No. 982184

Correspondence to: Dr. Wei Zhao, Department of Medicine, Nanjing Second Hospital, Zhongfu Road 1.1, Nanjing 210003, Jiangsu Province, China

Telephone: 25-3437440 Fax: 25-3439755

Received: July 11, 1999
Revised: October 10, 1999
Accepted: February 18, 2000
Published online: September 15, 2000

Abstract

AIM: To study the effect and alteration of hepatic blood flow as well as ultrastructure of hepatic tissue in chronic cholestatic hepatitis after hypebaric oxygenation (HBO).

METHODS: Using the hepatic rheometer and Doppler B-mode ultrasound equipment, the contractive wave of hepatic blood flow and blood flow of portal vein were tested; the biochemistry, immunohistochemistry and ultrastructure of hepatic tissue were determined and served as the evaluating indexes.

RESULTS: After the HBO treatment, the contractive wave of hepatic blood-flow in 76% patients and blood of right portal vein in 70% patients were increased, the improvement of serum ALT and BILI was 88.9% and 93.3% respectively. In addition, the swelling mitochondria, cholestasis of hepatic cells and capillaries reduced obviously; Kupffer’s cells decreased. There was significant difference (t = 2.85, P < 0.05) before and after HBO treatment.

CONCLUSION: It is suggested that the HBO could increase the blood flow of portal vein and arteries, improve the hepatic function, cholestatsis and inflammation.

Key Words: Hyperbaric oxygenation; Hepatitis liver; Ultrastructure

Citation: Zhao W, Liu W. Clinical and pathological study on the hyperbaric oxygenation treatment of chronic hepatitis. World J Gastroenterol 2000; 6(Suppl3): 132-132
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/132.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.132

Footnotes

E- Editor: Zhang FF