Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.132
Revised: October 10, 1999
Accepted: February 18, 2000
Published online: September 15, 2000
AIM: To study the effect and alteration of hepatic blood flow as well as ultrastructure of hepatic tissue in chronic cholestatic hepatitis after hypebaric oxygenation (HBO).
METHODS: Using the hepatic rheometer and Doppler B-mode ultrasound equipment, the contractive wave of hepatic blood flow and blood flow of portal vein were tested; the biochemistry, immunohistochemistry and ultrastructure of hepatic tissue were determined and served as the evaluating indexes.
RESULTS: After the HBO treatment, the contractive wave of hepatic blood-flow in 76% patients and blood of right portal vein in 70% patients were increased, the improvement of serum ALT and BILI was 88.9% and 93.3% respectively. In addition, the swelling mitochondria, cholestasis of hepatic cells and capillaries reduced obviously; Kupffer’s cells decreased. There was significant difference (t = 2.85, P < 0.05) before and after HBO treatment.
CONCLUSION: It is suggested that the HBO could increase the blood flow of portal vein and arteries, improve the hepatic function, cholestatsis and inflammation.