Relationship of traditional Chinese medicine and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in patients with gastric cancer and precancerous lessions

doi:10.3748/wjg.v6.iSuppl3.119

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 119-119
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.119

Relationship of traditional Chinese medicine and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in patients with gastric cancer and precancerous lessions

Wan-Dai Zhang, Xiao-Hu Wang, Jin-Zhang Zeng, Ya-Li Zhang, Yong Sun

Wan-Dai Zhang, Xiao-Hu Wang, Jin-Zhang Zeng, Ya-Li Zhang, Yong Sun, PLA Institute of Digestive Diseases, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Supported by the 95’ Foundation of Chinese PLA for tackling key problem, No. 96Z029

Correspondence to: Dr. Wan-Dai Zhang, Professor, PLA Institute of Digestive Diseases, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, Guangdong Province, China

Telephone: 20-85141212

Received: November 19, 1999
Revised: February 4, 2000
Accepted: March 18, 2000
Published online: September 15, 2000

Abstract

AIM: To study the relationship among typing of Traditional Chinese Medicine (TCM) and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in gastric cancer and precancerous lessions.

METHODS: According to TCM typing, 120 patients with chronic superficial gastritis, intestinal metaplasia, atypical hyperplasia and gastric cancer were divided into 4 groups: 21 patients with coexistence of cold and heat syndrome (group R), 22 patients with in coordination between the liver and the spleen (group U), 29 patients with deficiency of the spleen-yin (group I) and 48 patients with insufficiency of the spleen yang (group H). Protein expression of c-myc, p21 and p53 were detected immunohistochemically, and Hp were confirmed by modified Giemsa method.

RESULTS: The Hp infection of the group H was significantly higher (72.9%) than that of group R (38.1%, p < 0.01) and group U (40.9%, p < 0.01).Expression of c-myc, p21 and p53 were significantly related to Hp infection and severity of gastric mucosa lesions (group H > group I > group U > group R).

CONCLUSION: Hp infection, expression of oncogene and tumor suppresser genes were related to TCM typing. These parameters were helpful in identification of symptoms and signs and TCM differentiation diagnosis.

Key Words: Helicobacter pylori; Helicobacter infection; stomach neoplasms; Genes, suppressor, Tumor; Oncogenes; Precancerous conditions; Medicine, Chinese traditional

Citation: Zhang WD, Wang XH, Zeng JZ, Zhang YL, Sun Y. Relationship of traditional Chinese medicine and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in patients with gastric cancer and precancerous lessions. World J Gastroenterol 2000; 6(Suppl3): 119-119
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/119.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.119

Footnotes

E- Editor: Hu S