Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.119
Revised: February 4, 2000
Accepted: March 18, 2000
Published online: September 15, 2000
AIM: To study the relationship among typing of Traditional Chinese Medicine (TCM) and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in gastric cancer and precancerous lessions.
METHODS: According to TCM typing, 120 patients with chronic superficial gastritis, intestinal metaplasia, atypical hyperplasia and gastric cancer were divided into 4 groups: 21 patients with coexistence of cold and heat syndrome (group R), 22 patients with in coordination between the liver and the spleen (group U), 29 patients with deficiency of the spleen-yin (group I) and 48 patients with insufficiency of the spleen yang (group H). Protein expression of c-myc, p21 and p53 were detected immunohistochemically, and Hp were confirmed by modified Giemsa method.
RESULTS: The Hp infection of the group H was significantly higher (72.9%) than that of group R (38.1%, p < 0.01) and group U (40.9%, p < 0.01).Expression of c-myc, p21 and p53 were significantly related to Hp infection and severity of gastric mucosa lesions (group H > group I > group U > group R).
CONCLUSION: Hp infection, expression of oncogene and tumor suppresser genes were related to TCM typing. These parameters were helpful in identification of symptoms and signs and TCM differentiation diagnosis.