Diagnostic value of CagA IgG in the process to eradicate Helicobacter pylori

doi:10.3748/wjg.v6.iSuppl3.118

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Sep 15, 2000 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 118-118
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.118

Diagnostic value of CagA IgG in the process to eradicate Helicobacter pylori

Zhi-Bang Yang, Pi-Long Wang, Ming-Ming Gu, Li-Hao Chen, Quan Chen, Lin Zhan

Zhi-Bang Yang, Li-Hao Chen, Quan Chen, Department of Microbilogy, The Basic College, Chongqing University of Medical Science, Chongqing 400016, China

Pi-Long Wang, Department of Gastroentrology, The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China

Ming-Ming Gu, Lin Zhan, Chongqing Medical Information Institute, Chongqing 400006, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Zhi-Bang Yang, Professor, Department of Microbiology, The Basic College, Chongqing University of Medical Science, 1 Yixueyuan Lu, Chongqing 400016, China

Telephone: 23-68803788, 67861304

Received: May 19, 1999
Revised: January 24, 2000
Accepted: March 18, 2000
Published online: September 15, 2000

Abstract

AIM: To investigate the diagnostic value of CagA IgG in serum.

METHODS: Seventy three patients with peptic ulcer infected with Hp were eradicated by antibiotics therapy. At pretreatment, wk 9 and wk 20 after treatment, the detection of Hp in gastric muscosa by bacteriologic method were performed, and CagA and whole-cell antigen of Hp igG in serum by ELISA method were also performed at the same time.

RESULTS: The IgG titres of Hp CagA and whole-cell antigen changes in accordance with the efficacy of Hp eradicated. The former with an earlier appearance and a greater number of cases decreased to normal level in comparison with the latter.

CONCLUSION: CagA IgG is a better index for observing the effectiveness of the eradication of Hp.

Key Words: Helicobacter pylori; Antibiotics; Gastric mucosa; Serodiagnosis; CagA; IgG

Citation: Yang ZB, Wang PL, Gu MM, Chen LH, Chen Q, Zhan L. Diagnostic value of CagA IgG in the process to eradicate Helicobacter pylori. World J Gastroenterol 2000; 6(Suppl3): 118-118
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/118.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.118

Footnotes

Presented at The 1^st Chinese Congress of new found Infectious disease, Fuzhou, 13-17 October, 1997

E- Editor: Hu S