Abstracts
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 118-118
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.118
Diagnostic value of CagA IgG in the process to eradicate Helicobacter pylori
Zhi-Bang Yang, Pi-Long Wang, Ming-Ming Gu, Li-Hao Chen, Quan Chen, Lin Zhan
Zhi-Bang Yang, Li-Hao Chen, Quan Chen, Department of Microbilogy, The Basic College, Chongqing University of Medical Science, Chongqing 400016, China
Pi-Long Wang, Department of Gastroentrology, The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China
Ming-Ming Gu, Lin Zhan, Chongqing Medical Information Institute, Chongqing 400006, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Zhi-Bang Yang, Professor, Department of Microbiology, The Basic College, Chongqing University of Medical Science, 1 Yixueyuan Lu, Chongqing 400016, China
Telephone: 23-68803788, 67861304
Received: May 19, 1999
Revised: January 24, 2000
Accepted: March 18, 2000
Published online: September 15, 2000
Abstract

AIM: To investigate the diagnostic value of CagA IgG in serum.

METHODS: Seventy three patients with peptic ulcer infected with Hp were eradicated by antibiotics therapy. At pretreatment, wk 9 and wk 20 after treatment, the detection of Hp in gastric muscosa by bacteriologic method were performed, and CagA and whole-cell antigen of Hp igG in serum by ELISA method were also performed at the same time.

RESULTS: The IgG titres of Hp CagA and whole-cell antigen changes in accordance with the efficacy of Hp eradicated. The former with an earlier appearance and a greater number of cases decreased to normal level in comparison with the latter.

CONCLUSION: CagA IgG is a better index for observing the effectiveness of the eradication of Hp.

Keywords: Helicobacter pylori; Antibiotics; Gastric mucosa; Serodiagnosis; CagA; IgG