Isolated gastric variceal bleeding related to non-cirrhotic portal hypertension following oxaliplatin-based chemotherapy: A case report

Figure 1 Gastroscopic images taken before colon cancer surgery. A: Upper esophageal segment; B: Lower esophageal segment; C: The gastric fundus. No varices were found.

Figure 2 Abdominal enhanced computed tomography images. A: Arterial phase; B: Portal vein phase. There was no atrophy or cirrhotic features, and the liver parenchyma density was uniform; C: 3D vascular reconstruction of portal vein system. The blood flows of the portal and retropancreatic splenic veins were unobstructed without obvious widening of the inner diameters. Severe gastric fundal varices were clearly visible.

Figure 3 Pathological examination images. A, D: Hematoxylin and eosin (HE) staining showed obvious sinusoidal dilatation (A: 100 ×; D: 200 ×); B, E: Masson staining showed mild peri-sinusoidal fibrosis (B: 100 ×; E: 200 ×); C, F: HE staining showed obvious portal vein wall thickening and mild fibrosis in the portal area (C: 100 ×; F: 200 ×).

Figure 4 Gastroscopic examination and treatment images in our hospital. A: Image showing smooth esophageal mucosa without varices; B: Isolated gastric fundus varices (white arrow); C: Cyanoacrylate glue injection (white arrow) was administered for varices after blocking blood flow with a titanium clip to prevent ectopic embolism.