Helicobacter pylori in gastric cancer: Features of infection and their correlations with long-term results of treatment

Figure 1 The features of Helicobacter pylori localization in gastric mucosa in patients with gastric cancer. A: Coccoid forms of Helicobacter pylori (H. pylori) in the gastric pit. The some bacteria within the cytoplasm of epithelium cells (arrows); B: The spiral (black arrows) and coccoid (orange arrows) forms of H. pylori on the surface of superficial-foveolar gastric epithelium; C: The bacteria in the surface mucous gel layer of stomach (arrows); D: The point inclusions giving a positive reaction with antibodies to H. pylori within the cytoplasm of epithelial cells of deep gastric glands (arrows); E: The point inclusions giving a positive reaction with antibodies to H. pylori within the cytoplasm of the immune cells of the lamina propria of gastric mucosa (arrows); F: The point inclusions giving a positive reaction with antibodies to H. pylori within the cytoplasm of intraepithelial lymphocytes (arrows). Immunoperoxidase staining with anti-H. pylori antibody, immersion. Bars: A: 20 μm; B: 10 μm; C: 20 μm; D-F: 10 μm.

Figure 2 The features of Helicobacter pylori localization in omentum and lymph node in patients with gastric cancer. A: The small group of cocci located in the central part of the omentum adipocyte; B: The congestions of bacteria around the nucleus of lymphocytes in the paracortical area of lymph node. Immunoperoxidase staining with anti-Helicobacter pylori antibody, immersion, Bars: 10 μm.

Figure 3 10-year overall surviving and relapse-free surviving of patients with gastric cancer depending on the presence of antibiotic therapy 1-1. 5 mo before surgery (P = 0.02). A: 10-year overall surviving; B: Relapse-free surviving.

Figure 4 10-year overall surviving and relapse-free surviving of patients with T3-4N1-2M0 stages of gastric cancer depending on the presence of antibiotic therapy 1-1. 5 mo before surgery (P = 0.78). A: 10-year overall surviving; B: Relapse-free surviving.

Figure 5 10-year overall surviving and relapse-free surviving of patients with gastric cancer depending on the concentration of Helicobacter pylori coccoid forms in the gastric mucosa (P = 0. 02). A: 10-year overall surviving; B: Relapse-free surviving.