Senchukova MA, Tomchuk O, Shurygina EI. Helicobacter pylori in gastric cancer: Features of infection and their correlations with long-term results of treatment. World J Gastroenterol 2021; 27(37): 6290-6305 [PMID: 34712033 DOI: 10.3748/wjg.v27.i37.6290]
Corresponding Author of This Article
Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street 6, Orenburg 460000, Russia. masenchukova@yandex.com
Research Domain of This Article
Oncology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 7, 2021; 27(37): 6290-6305 Published online Oct 7, 2021. doi: 10.3748/wjg.v27.i37.6290
Helicobacter pylori in gastric cancer: Features of infection and their correlations with long-term results of treatment
Marina A Senchukova, Olesya Tomchuk, Elena I Shurygina
Marina A Senchukova, Department of Oncology, Orenburg State Medical University, Orenburg 460000, Russia
Olesya Tomchuk, Department of Histology, Cytology, Embryology, Orenburg State Medical University, Orenburg 460000, Russia
Elena I Shurygina, Department of Pathology, Orenburg State Medical University, Orenburg 460000, Russia
Author contributions: Senchukova MA wrote the paper; Tomchuk O and Shurygina EI perfomed the collected the data.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Orenburg State Medical University.
Informed consent statement: All patients provided written informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interests related to the publication of this study.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street 6, Orenburg 460000, Russia. masenchukova@yandex.com
Received: April 30, 2021 Peer-review started: April 30, 2021 First decision: June 17, 2021 Revised: June 21, 2021 Accepted: August 31, 2021 Article in press: August 31, 2021 Published online: October 7, 2021
ARTICLE HIGHLIGHTS
Research background
Gastric cancer (GC) continues to be one of the most common malignant diseases in the world. It is known that Helicobacter pylori (H. pylori) infection, initiating the development of a chronic inflammatory process in the gastric mucosa (GM), is the leading risk factor for GC. At the same time, clinical studies indicate that inflammatory infiltration of the tumor stroma and surrounding tissues can have an important prognostic value and affect the long-term results of malignant neoplasm treatment.
Research motivation
It is still not clear whether H. pylori is involved only in the initiation of the tumor process in the stomach, or whether it can affect the mechanisms of tumor progression.
Research objectives
The aim of this study was to establish the features of H. pylori infection in patients with GC and their correlations with clinical and morphological characteristics of diseases and long-term results of treatment.
Research methods
In this prospective observational study, we included all patients with GC who had undergone radical surgery (R0) between May 2007 and March 2010 at the Orenburg Regional Clinical Oncology Center. Features of the H. pylori infection and its severity was determined by rapid urease test and by immunohistochemically using the antibody to H. pylori. The data obtained we compared with clinical features of GC: Stage, localization, histology, the presence of antibiotic therapy (AT) before surgery, and 10-year overall and disease-free survival.
Research results
We found H. pylori infection in the adjacent to the tumor GM in 84.5% of cases. We have established that the coccoid forms of H. pylori predominate in the GM of patients with GC. A high rate of infection by coccoid forms of H. pylori has been associated with more aggressive type of GC, advanced stage, and decline of a 10-year overall and disease-free survival. The presence of AT 1-1.5 mo before the operation was associated with an improvement in the 10-year survival rate of patients with local (T1-3N0M0), but not advanced (T3-4N1-2M0) stages of GC.
Research conclusions
These results indicate that H. pylori may be associated not only with induction but also with the progression of GC.
Research perspectives
The results obtained do not allow one to draw unambiguous conclusions about the role of H. pylori in the progression of GC. Further appropriate prospective studies regarding the role of H. pylori in the progression of GC are obviously advisable.
