Neurotensin receptor 1 overexpression in inflammatory bowel diseases and colitis-associated neoplasia

Figure 1 Neurotensin receptor 1 expression in colonic mucosa under different conditions. A and B: Normal colonic mucosa; C and D: Active chronic colitis; E and F: Dysplasia-associated lesions or masses with low-grade dysplasia; G and H: Invasive adenocarcinoma (hematoxylin and eosin histology and neurotensin receptor 1 expression immunohistochemistry).

Figure 2 Neurotensin receptor 1 expression. A: Neurotensin receptor 1 (NTSR1) expression in colonic mucosa under different conditions in cases of colectomy for inflammatory bowel diseases (IBD) (percentage of cases in each subgroup); B: NTSR1 expression in colonic mucosa with dysplasia and carcinoma in cases of colectomy for IBD (percentage of cases in each subgroup); C: Comparison of colonic mucosal NTSR1 expression in sporadic neoplasia and colitis-associated neoplasia (percentage of cases in each subgroup). LGD: Low-grade dysplasia; HGD: High-grade dysplasia; DALM: Dysplasia-associated lesions or masses; CACRC: Colitis-associated colorectal carcinoma; SAP: Sporadic colorectal carcinoma; SCRC: Sporadic colorectal adenomatous polyp.