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World J Gastroenterol. Jul 28, 2013; 19(28): 4504-4510
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4504
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4504
Neurotensin receptor 1 overexpression in inflammatory bowel diseases and colitis-associated neoplasia
Xianyong Gui, Shuhong Liu, Yuchu Yan, Zuhua Gao, Calgary Laboratory Services and Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta T2N 2T9, Canada
Author contributions: Gui X is the guarantor of the work as well as the main/lead researcher who was instrumental in the design, planning, selecting tissue samples, conducting the study, data review and analysis of the results, and writing the manuscript; Liu S was the major contributor to the laboratory work; Yan Y assisted with the laboratory work; Gao Z contributed partly to the results review/analysis, comments, and review of the manuscript.
Supported by Calgary Laboratory Services Internally Supported Research, RS09-533
Correspondence to: Xianyong Gui, MD, PhD, Calgary Laboratory Services and Department of Pathology and Laboratory Medicine, University of Calgary, 1403-29 Street NW, Calgary, Alberta T2N 2T9, Canada. xsean.gui@cls.ab.ca
Telephone: +1-403-9448507 Fax: +1-403-9444748
Received: December 3, 2012
Revised: March 23, 2013
Accepted: April 13, 2013
Published online: July 28, 2013
Revised: March 23, 2013
Accepted: April 13, 2013
Published online: July 28, 2013
Core Tip
Core tip: Neurotensin receptor 1 (NTSR1) in colonic epithelial cells is overexpressed in inflammatory bowel diseases, in a stepwise fashion with the sequential progress from inflammation to low-grade dysplasia, high-grade dysplasia, and carcinoma. Both colitis-associated and sporadic dysplasia/carcinoma showed a similar pattern of NTSR1 overexpression. NTSR1 could be a potential pharmacological target in the treatment of inflammatory bowel diseases and prevention of colitis-associated neoplasia.