Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2025; 31(2): 97239
Published online Jan 14, 2025. doi: 10.3748/wjg.v31.i2.97239
Clinical effects of phospholipase D2 in attenuating acute pancreatitis
Jin-Wei Niu, Guo-Chao Zhang, Wu Ning, Hai-Bin Liu, Hua Yang, Chao-Feng Li
Jin-Wei Niu, Guo-Chao Zhang, Wu Ning, Hai-Bin Liu, Hua Yang, Chao-Feng Li, Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Niu JW and Li CF contributed to the conception and design of the study; Niu JW, Zhang GC, Ning W, Liu HB, Yang H, and Li CF participated in the clinical practice, including diagnosis, treatment, consultation and follow up of patients; Zhang GC and Ning W contributed to the acquisition of data; Liu HB and Yang H contributed to the analysis of data; Niu JW wrote the manuscript; Li CF revised the manuscript. All authors approved the final version of the manuscript.
Institutional review board statement: The study protocol was approved by the Ethics Committee of China-Japan Friendship Hospital, approval No. 23-B045, and the study was performed in accordance with the Helsinki II declaration.
Informed consent statement: Informed consent was obtained from all the study subjects before enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data is provided within the manuscript or supplementary information files.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao-Feng Li, MD, Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan Dongjie, Beijing 100029, China. 13488880631@139.com
Received: May 26, 2024
Revised: October 8, 2024
Accepted: November 26, 2024
Published online: January 14, 2025
Processing time: 205 Days and 17.7 Hours
Core Tip

Core Tip: This research substantiated the indispensable role of phospholipase D2 (PLD2) in the pathological progression of acute pancreatitis. Moreover, the varying protein expression levels of PLD2 among patients with distinct degrees of acute pancreatitis exhibited an inverse relationship with disease severity. Moreover, this study revealed PLD2’s potential to mitigate acute pancreatitis by restricting neutrophil movement.