Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2025; 31(14): 105420
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.105420
Gut microbiota plays a key role in the development of colorectal cancer
Ying-Ling Liu, Jie Liu
Ying-Ling Liu, Jie Liu, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Author contributions: Liu YL contributed to draft of the manuscript; Liu J contributed to critical revision of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Supported by Research Project of the Chinese Digestive Early Cancer Physicians' Joint Growth Program, No. GTCZ-2021-AH-34-0012.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Liu, MD, PhD, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com
Received: January 22, 2025
Revised: March 5, 2025
Accepted: March 10, 2025
Published online: April 14, 2025
Processing time: 79 Days and 21.2 Hours
Core Tip

Core Tip: Colorectal cancer (CRC) represents the most prevalent malignancy within the digestive system, characterized by elevated rates of mortality and morbidity. In this letter, we provide commentary on the research conducted by Darnindro et al, which identified the four most dominant phyla present in their study as Firmicutes, Proteobacteria, Bacteroidetes, and Fusobacteria. Importantly, the study revealed a significant disparity in beta diversity at both the genus and species levels when comparing groups with CRC to those without.