Liu YL, Liu J. Gut microbiota plays a key role in the development of colorectal cancer. World J Gastroenterol 2025; 31(14): 105420 [DOI: 10.3748/wjg.v31.i14.105420]
Corresponding Author of This Article
Jie Liu, MD, PhD, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 14, 2025; 31(14): 105420 Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.105420
Gut microbiota plays a key role in the development of colorectal cancer
Ying-Ling Liu, Jie Liu
Ying-Ling Liu, Jie Liu, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Author contributions: Liu YL contributed to draft of the manuscript; Liu J contributed to critical revision of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Supported by Research Project of the Chinese Digestive Early Cancer Physicians' Joint Growth Program, No. GTCZ-2021-AH-34-0012.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Liu, MD, PhD, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com
Received: January 22, 2025 Revised: March 5, 2025 Accepted: March 10, 2025 Published online: April 14, 2025 Processing time: 79 Days and 21.2 Hours
Abstract
This letter addresses the recently published manuscript by Darnindro et al, which investigates the diversity and composition of colonic mucosal microbiota in Indonesian patients with and without colorectal cancer (CRC). Although the analysis revealed no statistically significant differences in alpha diversity between the CRC and non-CRC groups, the authors identified notable distinctions in the composition and diversity of colonic mucosal microbiota among patients with CRC compared to those without. At the genus level, a statistically significant difference in microbiota composition was documented between the two cohorts. Specifically, the genera Bacteroides, Campylobacter, Peptostreptococcus, and Parvimonas were found to be elevated in individuals with CRC, while Faecalibacterium, Haemophilus, and Phocaeicola were more prevalent in the non- CRC group.
Core Tip: Colorectal cancer (CRC) represents the most prevalent malignancy within the digestive system, characterized by elevated rates of mortality and morbidity. In this letter, we provide commentary on the research conducted by Darnindro et al, which identified the four most dominant phyla present in their study as Firmicutes, Proteobacteria, Bacteroidetes, and Fusobacteria. Importantly, the study revealed a significant disparity in beta diversity at both the genus and species levels when comparing groups with CRC to those without.
