Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2025; 31(1): 99954
Published online Jan 7, 2025. doi: 10.3748/wjg.v31.i1.99954
Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis
Chun-Lin Ou, Jing Zhang
Jing Zhang, Department of Immunology, School of Basic Medicine, Central South University, Changsha 410000, Hunan Province, China
Chun-Lin Ou, Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Author contributions: Zhang J contributed to writing - review & editing; Ou CL contributed to funding acquisition, project administration, and supervision; all authors have read and approved the final manuscript.
Supported by the Central South University Innovation-Driven Research Programme, No. 2023CXQD075.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Lin Ou, PhD, Associate Professor, Department of Pathology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. ouchunlin@csu.edu.cn
Received: August 3, 2024
Revised: October 24, 2024
Accepted: November 19, 2024
Published online: January 7, 2025
Processing time: 127 Days and 16.8 Hours
Core Tip

Core Tip: The dysregulated expression of tRNA-derived small RNAs (tsRNAs) in acute pancreatitis (AP) reveals the molecular mechanism by which tsRNAs affect the occurrence and development of AP, and can be used as diagnostic markers and potential therapeutic targets. In cell and animal models, the inhibition or overexpression of tsRNA has been shown to influence AP development. The results showed that tsRNAs accelerated AP progression by inducing an increase in inflammatory factors and promoting cell death (including pyroptosis and ferroptosis).