Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2024; 30(47): 5097-5103
Published online Dec 21, 2024. doi: 10.3748/wjg.v30.i47.5097
Role of gut microbiota and Helicobacter pylori in inflammatory bowel disease through immune-mediated synergistic actions
Zhi-Hao Deng, Xin Li, Li Liu, Hai-Min Zeng, Bo-Fan Chen, Jie Peng
Zhi-Hao Deng, Li Liu, Hai-Min Zeng, Bo-Fan Chen, Jie Peng, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Xin Li, The First Clinical Medical College, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 310006, Jiangxi Province, China
Co-first authors: Zhi-Hao Deng and Xin Li.
Author contributions: Deng ZH and Li X wrote the manuscript; Liu L, Zeng HM, and Chen BF contributed to this paper; Peng J designed and implemented the content of this manuscript, and revised and reviewed the manuscript; all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Peng, MD, Doctor, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. jie_peng@email.ncu.edu.cn
Received: September 5, 2024
Revised: October 19, 2024
Accepted: November 4, 2024
Published online: December 21, 2024
Processing time: 82 Days and 3.3 Hours
Core Tip

Core Tip: The gut microbiota and Helicobacter pylori (H. pylori) are crucial in maintaining immune balance. H. pylori may protect against inflammatory bowel disease (IBD) by regulating the immune system and suppressing excessive inflammation. It also influences the gut microbiota, potentially modulating IBD by adjusting microbiota abundance and through immune-mediated synergistic effects. However, the relationship between H. pylori and the gut microbiota needs further investigation. Understanding these interactions could inform the development of new IBD treatments and therapeutic strategies.