Deng ZH, Li X, Liu L, Zeng HM, Chen BF, Peng J. Role of gut microbiota and Helicobacter pylori in inflammatory bowel disease through immune-mediated synergistic actions. World J Gastroenterol 2024; 30(47): 5097-5103 [PMID: 39713161 DOI: 10.3748/wjg.v30.i47.5097]
Corresponding Author of This Article
Jie Peng, MD, Doctor, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. jie_peng@email.ncu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 21, 2024; 30(47): 5097-5103 Published online Dec 21, 2024. doi: 10.3748/wjg.v30.i47.5097
Role of gut microbiota and Helicobacter pylori in inflammatory bowel disease through immune-mediated synergistic actions
Zhi-Hao Deng, Xin Li, Li Liu, Hai-Min Zeng, Bo-Fan Chen, Jie Peng
Zhi-Hao Deng, Li Liu, Hai-Min Zeng, Bo-Fan Chen, Jie Peng, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Xin Li, The First Clinical Medical College, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 310006, Jiangxi Province, China
Co-first authors: Zhi-Hao Deng and Xin Li.
Author contributions: Deng ZH and Li X wrote the manuscript; Liu L, Zeng HM, and Chen BF contributed to this paper; Peng J designed and implemented the content of this manuscript, and revised and reviewed the manuscript; all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Peng, MD, Doctor, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. jie_peng@email.ncu.edu.cn
Received: September 5, 2024 Revised: October 19, 2024 Accepted: November 4, 2024 Published online: December 21, 2024 Processing time: 82 Days and 3.3 Hours
Abstract
A recent study published in the World Journal of Gastroenterology, suggests that transplanting the gut microbiota from healthy donors can alleviate the pathological processes linked to inflammatory bowel disease (IBD), particularly Crohn's disease. In addition, that paper illustrates the effect of changes in the gut microbiota on IBD and points out that altered mesenteric adipose tissue caused by the gut microbiota and creeping fat lead to increased inflammation, which exacerbates IBD. Moreover, recent research has shown that the interaction between Helicobacter pylori (H. pylori) and the gut microbiota is mediated through immune mechanisms, resulting in a synergistic impact on IBD. Therefore, in this manuscript, we will focus on the role of the gut microbiota and H. pylori in the immune response to IBD, as well as the possible impact of H. pylori on the gut microbiota. We will also explore their individual and synergistic immune effects on IBD and look at future therapeutic perspectives for IBD.
Core Tip: The gut microbiota and Helicobacter pylori (H. pylori) are crucial in maintaining immune balance. H. pylori may protect against inflammatory bowel disease (IBD) by regulating the immune system and suppressing excessive inflammation. It also influences the gut microbiota, potentially modulating IBD by adjusting microbiota abundance and through immune-mediated synergistic effects. However, the relationship between H. pylori and the gut microbiota needs further investigation. Understanding these interactions could inform the development of new IBD treatments and therapeutic strategies.
