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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2024; 30(46): 4864-4879
Published online Dec 14, 2024. doi: 10.3748/wjg.v30.i46.4864
Published online Dec 14, 2024. doi: 10.3748/wjg.v30.i46.4864
Lipocalin-2 and intestinal diseases
Zhong-Xu Zhang, Jian Peng, Wei-Wei Ding, Department of Trauma and Acute Care Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, Jiangsu Province, China
Co-first authors: Zhong-Xu Zhang and Jian Peng.
Author contributions: Zhang ZX contributed to the conceptualization, writing-original draft preparation, and visualization of this manuscript; Zhang ZX and Peng J participated in the writing-review & editing, they are contributed equally to this article; Ding WW contributed to the supervision. All authors have read and agreed to the published version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82270587.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Wei Ding, MD, PhD, Professor, Department of Trauma and Acute Care Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China.
Received: April 27, 2024
Revised: September 25, 2024
Accepted: November 4, 2024
Published online: December 14, 2024
Processing time: 208 Days and 3.8 Hours
Revised: September 25, 2024
Accepted: November 4, 2024
Published online: December 14, 2024
Processing time: 208 Days and 3.8 Hours
Core Tip
Core Tip: Lipocalin-2, also referred to as neutrophil gelatinase-associated lipocalin or 24p3, plays a pivotal role in diverse physiological processes and pathological injuries. In this review, we delineate its structure and the mechanisms underlying its action, elucidate its multifaceted interplay with the immune environment and its relevance to gastrointestinal disorders, thereby providing insights into potential avenues using targeted therapies directed to this multifunctional protein.