Zhang ZX, Peng J, Ding WW. Lipocalin-2 and intestinal diseases. World J Gastroenterol 2024; 30(46): 4864-4879 [DOI: 10.3748/wjg.v30.i46.4864]
Corresponding Author of This Article
Wei-Wei Ding, MD, PhD, Professor, Department of Trauma and Acute Care Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. dingwei_nju@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 14, 2024; 30(46): 4864-4879 Published online Dec 14, 2024. doi: 10.3748/wjg.v30.i46.4864
Lipocalin-2 and intestinal diseases
Zhong-Xu Zhang, Jian Peng, Wei-Wei Ding
Zhong-Xu Zhang, Jian Peng, Wei-Wei Ding, Department of Trauma and Acute Care Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, Jiangsu Province, China
Co-first authors: Zhong-Xu Zhang and Jian Peng.
Author contributions: Zhang ZX contributed to the conceptualization, writing-original draft preparation, and visualization of this manuscript; Zhang ZX and Peng J participated in the writing-review & editing, they are contributed equally to this article; Ding WW contributed to the supervision. All authors have read and agreed to the published version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82270587.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Wei Ding, MD, PhD, Professor, Department of Trauma and Acute Care Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. dingwei_nju@hotmail.com
Received: April 27, 2024 Revised: September 25, 2024 Accepted: November 4, 2024 Published online: December 14, 2024 Processing time: 208 Days and 3.8 Hours
Abstract
Dysfunction of the intestinal barrier is a prevalent phenomenon observed across a spectrum of diseases, encompassing conditions such as mesenteric artery dissection, inflammatory bowel disease, cirrhosis, and sepsis. In these pathological states, the integrity of the intestinal barrier, which normally serves to regulate the selective passage of substances between the gut lumen and the bloodstream, becomes compromised. This compromised barrier function can lead to a range of adverse consequences, including increased permeability to harmful substances, the translocation of bacteria and their products into systemic circulation, and heightened inflammatory responses within the gut and beyond. Understanding the mechanisms underlying intestinal barrier dysfunction in these diverse disease contexts is crucial for the development of targeted therapeutic interventions aimed at restoring barrier integrity and ameliorating disease progression. Lipocalin-2 (LCN2) expression is significantly upregulated during episodes of intestinal inflammation, making it a pivotal indicator for gauging the extent of such inflammatory processes. Notably, however, LCN2 derived from distinct cellular sources, whether intestinal epithelial cells or immune cells, exhibits notably divergent functional characteristics. Furthermore, the multifaceted nature of LCN2 is underscored by its varying roles across different diseases, sometimes even demonstrating contradictory effects.
Core Tip: Lipocalin-2, also referred to as neutrophil gelatinase-associated lipocalin or 24p3, plays a pivotal role in diverse physiological processes and pathological injuries. In this review, we delineate its structure and the mechanisms underlying its action, elucidate its multifaceted interplay with the immune environment and its relevance to gastrointestinal disorders, thereby providing insights into potential avenues using targeted therapies directed to this multifunctional protein.
