Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2024; 30(31): 3689-3704
Published online Aug 21, 2024. doi: 10.3748/wjg.v30.i31.3689
Role of gut microbiota in Crohn’s disease pathogenesis: Insights from fecal microbiota transplantation in mouse model
Qiang Wu, Lian-Wen Yuan, Li-Chao Yang, Ya-Wei Zhang, Heng-Chang Yao, Liang-Xin Peng, Bao-Jia Yao, Zhi-Xian Jiang
Qiang Wu, Lian-Wen Yuan, Li-Chao Yang, Ya-Wei Zhang, Heng-Chang Yao, Liang-Xin Peng, Bao-Jia Yao, Zhi-Xian Jiang, Geriatric Surgery of Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Yuan LW and Wu Q conceived and designed the study; Wu Q wrote the first draft of the manuscript; Yuan LW critically revised the manuscript for important intellectual content; Yang LC, Zhang YW, Yao BJ, and Peng LX generated and analyzed the data and participated in drafting the manuscript; Yao HC and Jiang ZX recruited patients to this study and searched relevant literature; and all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82270590.
Institutional review board statement: The study protocol was approved by the Institutional Review Board of The Second Xiangya Hospital, CSU (approval No. 2022-333).
Institutional animal care and use committee statement: The animal use protocol listed below has been reviewed and approved by the Institutional Animal Care and Use Committee (IACUC), The Second Xiangya Hospital, Central South University (approval No. 2022560).
Conflict-of-interest statement: The authors have no conflicts of interest and financial disclosures.
Data sharing statement: All data analyzed in this paper have been provided in the main manuscript and in supplementary documents, and it is permissible to contact the corresponding author to try to obtain it if necessary.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian-Wen Yuan, PhD, Chief Physician, Professor, Geriatric Surgery of Department of General Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. yuanlianwen@csu.edu.cn
Received: March 1, 2024
Revised: May 24, 2024
Accepted: July 26, 2024
Published online: August 21, 2024
Processing time: 166 Days and 15.8 Hours
Core Tip

Core Tip: The present study evaluated the complex interplay among creeping fat, inflammation, and intestinal microbiota involved in the pathogenesis of Crohn’s disease (CD). The intestinal microbiota was found to play a multifaceted role, mediating the properties of creeping fat while affecting the inflammatory and fibrotic phenotypes associated with CD.