Published online Aug 21, 2024. doi: 10.3748/wjg.v30.i31.3689
Revised: May 24, 2024
Accepted: July 26, 2024
Published online: August 21, 2024
Processing time: 166 Days and 15.8 Hours
Inflammatory bowel disease, particularly Crohn’s disease (CD), has been asso
To evaluate the complex interplay among MAT, creeping fat, inflammation, and gut microbiota in CD.
Intestinal tissue and MAT were collected from 12 patients with CD. Histological manifestations and protein expression levels were analyzed to determine lesion characteristics. Fecal samples were collected from five recently treated CD pa
Pathological examination of MAT showed significant differences between CD-affected and unaffected colons, including significant differences in gut microbiota structure. Fetal microbiota transplantation (FMT) from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced CD ameliorated CD symptoms, whereas FMT from CD patients into these mice exacerbated CD symptoms. Notably, FMT influenced intestinal permeability, barrier function, and levels of proinflammatory factors and adipokines. Furthermore, FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced CD.
Gut microbiota play a critical role in the histopathology of CD. Targeting MAT and creeping fat may therefore have potential in the treatment of patients with CD.
Core Tip: The present study evaluated the complex interplay among creeping fat, inflammation, and intestinal microbiota involved in the pathogenesis of Crohn’s disease (CD). The intestinal microbiota was found to play a multifaceted role, mediating the properties of creeping fat while affecting the inflammatory and fibrotic phenotypes associated with CD.