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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2023; 29(4): 682-691
Published online Jan 28, 2023. doi: 10.3748/wjg.v29.i4.682
Published online Jan 28, 2023. doi: 10.3748/wjg.v29.i4.682
Gaseous metabolites as therapeutic targets in ulcerative colitis
Chu K Yao, Department of Gastroenterology, Monash University, Melbourne 3004, Australia
Chen Sarbagili-Shabat, Pediatric Gastroenterology Unit, PIBD Research Center, Wolfson Medical Center, Holon 5822012, Israel
Author contributions: Yao CK and Sarbagili-Shabat C conducted the literature search; Yao CK devised headings for the article; and all authors drafted, wrote the article and approved of the final content.
Conflict-of-interest statement: Yao CK has received support for investigator-initiated grants from Atmo Biosciences. She also works in a department that financially benefits from the sales of a digital application and booklets on the low fermentable oligosaccharides, disaccharides, monosaccharides and polyols diet. Funds raised contribute to research of the Department of Gastroenterology and to the University. She does not receive personal remuneration. Sarbagili-Shabat C has no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chu K Yao, PhD, RN, Senior Research Fellow, Department of Gastroenterology, Monash University, Level 6, Alfred Centre, 99 Commercial Road, Melbourne 3004, Australia. chu.yao@monash.edu
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: November 15, 2022
Revised: December 19, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: January 28, 2023
Peer-review started: September 20, 2022
First decision: November 15, 2022
Revised: December 19, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: January 28, 2023
Core Tip
Core Tip: There is room to develop efficacious dietary therapies in ulcerative colitis (UC) by targeting underlying pathogenic mechanisms. Emerging data indicates that dietary factors play a significant role in modulating two gaseous metabolites, hydrogen sulphide and nitric oxide, that affect the integrity of the colonic mucosal barrier in UC. These gases are produced by the colonic microbiota in response to sulphur-containing protein and to a lesser extent, inorganic sulphur (sulphates and sulphites), but suppressed by the presence of fermentable fibre. Preliminary work suggests that a multi-prong diet that targets reduction of these gases have therapeutic potential and further randomised-controlled trials are underway.