Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2023; 29(32): 4900-4911
Published online Aug 28, 2023. doi: 10.3748/wjg.v29.i32.4900
Hepatitis B virus infection in patients with Wilson disease: A large retrospective study
Hua-Ying Zhou, Xu Yang, Kai-Zhong Luo, Yong-Fang Jiang, Wen-Long Wang, Jun Liang, Ming-Ming Li, Hong-Yu Luo
Hua-Ying Zhou, Xu Yang, Kai-Zhong Luo, Yong-Fang Jiang, Wen-Long Wang, Jun Liang, Ming-Ming Li, Hong-Yu Luo, Department of Infectious Diseases, Institute of Hepatology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Zhou HY, Yang X, and Luo HY contributed to study conception, design and writing of the article; Yang X, Luo KZ, Jiang YF, Wang WL, Liang J, Li MM, and Luo HY contributed to data acquisition, data analysis and interpretation; Zhou HY, Yang X, and Luo HY contributed to editing, reviewing, and final approval of the article; and all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethical Committee of the Second Xiangya Hospital of Central South University, (2022) Lun Shen [Lin Yan] No. (194).
Informed consent statement: Informed consent was waived by the Ethical Committee of the Second Xiangya Hospital of Central South University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author luohongyu@csu.edu.cn.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared according to the STROBE statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Yu Luo, MD, Associate Professor, Department of Infectious Diseases, Institute of Hepatology, The Second Xiangya Hospital, Central South University, No. 139 Renming Road, Changsha 410011, Hunan Province, China. luohongyu@csu.edu.cn
Received: June 4, 2023
Peer-review started: June 4, 2023
First decision: July 8, 2023
Revised: July 20, 2023
Accepted: July 31, 2023
Article in press: July 31, 2023
Published online: August 28, 2023
Processing time: 81 Days and 14.7 Hours
Core Tip

Core Tip: Data on hepatitis B virus (HBV) infection in patients with Wilson disease (WD) are limited. This is the largest investigation of HBV infection in WD patients. The most important finding of this study was the identification of 19 patients with concurrent WD and chronic hepatitis B (CHB) infection. The total prevalence of current HBV infection in patients with WD was 2.1%. The diagnosis of WD in CHB patients is usually missed. HBV infection is an independent risk factor for severe liver disease in WD patients. The diagnosis of WD should be ruled out in some patients with CHB infection.