Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2023; 29(30): 4685-4700
Published online Aug 14, 2023. doi: 10.3748/wjg.v29.i30.4685
Diagnostic value of conventional endoscopic ultrasound for lymph node metastasis in upper gastrointestinal neoplasia: A meta-analysis
Cong Chen, Ya-Lan Song, Zhen-Yu Wu, Jing Chen, Yao Zhang, Lei Chen
Cong Chen, Ya-Lan Song, Zhen-Yu Wu, Jing Chen, Lei Chen, Institute of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
Yao Zhang, Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, China
Author contributions: Chen C and Chen L conceived and designed the study; Chen C and Song YL contributed to the literature search, study selection and drafted the manuscript; Chen C, Wu ZY, and Chen L extracted the data; Chen C and Chen J contributed to the quality assessment; Chen C, Song YL, and Zhang Y analyzed the data; Chen C, Wu ZY, and Chen J interpreted the data; Wu ZY edited the manuscript; Chen J revised the manuscript; Chen L and Zhang Y contributed to the critical revision; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Chen, MD, PhD, Professor, Institute of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), No. 30 Gaotanyan Main Street, Xinqiao Street, Shapingba District, Chongqing 400038, China. chenlei_1977603@126.com
Received: May 5, 2023
Peer-review started: May 5, 2023
First decision: July 9, 2023
Revised: July 16, 2023
Accepted: July 27, 2023
Article in press: July 27, 2023
Published online: August 14, 2023
Core Tip

Core Tip: This meta-analysis examined the diagnostic value of conventional endoscopic ultrasound (EUS) for lymph node metastasis (LNM) in upper gastrointestinal neoplasia. The pooled analyses of 2986 patients from 22 studies performed herein show that conventional EUS has certain clinical value and can assist in the detection of LNM in upper gastrointestinal neoplasia, but it cannot be used as a confirmatory or exclusionary test. More high-quality studies are needed to further verify the diagnostic value of EUS and determine the best diagnostic criteria.