Jin Y, Guo YH, Li JC, Li Q, Ye D, Zhang XX, Li JT. Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy. World J Gastroenterol 2023; 29(24): 3748-3757 [PMID: 37426320 DOI: 10.3748/wjg.v29.i24.3748]
Corresponding Author of This Article
Jiang-Tao Li, FACS, MD, Chief Doctor, Professor, Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zrljt@zju.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 28, 2023; 29(24): 3748-3757 Published online Jun 28, 2023. doi: 10.3748/wjg.v29.i24.3748
Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy
Yun Jin, Ying-Hao Guo, Jia-Cheng Li, Qi Li, Dan Ye, Xiao-Xiao Zhang, Jiang-Tao Li
Yun Jin, Ying-Hao Guo, Qi Li, Dan Ye, Xiao-Xiao Zhang, Jiang-Tao Li, Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Jia-Cheng Li, Department of General Surgery, Yuhuan Second People’s Hospital, Taizhou 317600, Zhejiang Province, China
Author contributions: Jin Y and Guo YH wrote the paper; Jin Y and Li JT conceived and designed the study; Li JC, Li Q and Li JT reviewed and edited the manuscript; Ye D and Zhang XX created figures; all authors read and approved the manuscript; Jin Y and Guo YH contributed equally to this work.
Supported bythe Natural Science Foundation of Zhejiang Province, No. LQ21H030005.
Conflict-of-interest statement: We declare that we have no conflict of interest to this work.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Tao Li, FACS, MD, Chief Doctor, Professor, Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zrljt@zju.edu.cn
Received: April 3, 2023 Peer-review started: April 3, 2023 First decision: May 4, 2023 Revised: May 13, 2023 Accepted: June 2, 2023 Article in press: June 2, 2023 Published online: June 28, 2023
Core Tip
Core Tip: Low regenerative ability of the liver remaining after partial hepatectomy may lead to serious complications including liver failure. The proliferation of liver sinusoidal endothelial cells (LSECs) is slower and occurs later compared to that of hepatocytes, leading to a delayed recovery of the hepatic sinusoids and impaired liver regeneration. Hepatocytes secrete vascular endothelial growth factor (VEGF) that promotes the proliferation of LSECs, and supplementation of exogenous VEGF after hepatectomy also increases the number of LSECs in the remaining liver, thus promoting the reestablishment of the hepatic sinusoids and accelerating liver regeneration. This review summarized the most recent findings on liver regeneration and new strategies for the localized delivery in the liver.
