Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2023; 29(13): 1994-2000
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1994
Gut microbiota predicts the diagnosis of celiac disease in Saudi children
Mohammad El Mouzan, Asaad Assiri, Ahmed Al Sarkhy
Mohammad El Mouzan, Asaad Assiri, Ahmed Al Sarkhy, Department of Pediatrics (Gastroenterology Unit), King Saud University, Riyadh 11461, Saudi Arabia
Author contributions: El Mouzan M designed the study, interpreted the data, drafted, and revised the manuscript; Assiri A and Al Sarkhy A participated equally in the data management and revision; and all authors approved the final manuscript.
Supported by the Deanship of Scientific Research, King Saud University, No. RGP-1441-007.
Institutional review board statement: The study was reviewed and approved by the College of Medicine IRB (No. 14/4464/IRB).
Informed consent statement: All parents and children received informed consent/assent before participation in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data is available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammad El Mouzan, MD, Full Professor, Department of Pediatrics (Gastroenterology Unit), King Saud University, 1, King Abdullah Street, Riyadh 11461, Saudi Arabia. melmouzan@ksu.edu.sa
Received: November 2, 2022
Peer-review started: November 2, 2022
First decision: December 11, 2022
Revised: December 29, 2022
Accepted: March 20, 2023
Article in press: March 20, 2023
Published online: April 7, 2023
Processing time: 155 Days and 22.3 Hours
Core Tip

Core Tip: Celiac disease (CeD) is known to be associated with the microbiota. In this study, the combination of bacterial and viral taxa in stools and mucosal bacterial taxa were the strongest predictors of celiac disease. In addition, we report important bacterial markers, namely, Bacteroides intestinalis and Burkholderiales bacterium 1-1-47, which were reduced in children with CeD, suggesting a protective role in children with CeD.