Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1994
Peer-review started: November 2, 2022
First decision: December 11, 2022
Revised: December 29, 2022
Accepted: March 20, 2023
Article in press: March 20, 2023
Published online: April 7, 2023
Dysbiosis associated with celiac disease (CeD) is well known and beneficial and harmful associations have been reported.
The role of the microbiota in predicting CeD has rarely been described.
To search for a microbial signature that may help in the diagnosis and prevention of CeD.
Metagenomic analysis of microbial DNA in mucosa and stool of children with newly diagnosed CeD calculation of the area under the curve to evaluate the predictive power of the whole microbiota and use of rendom forest analysis to identify important microbes in distinguishing CeD groups from controls.
Very high discriminatory power of combined bacteria and viruses (81.8%) in fecal samples and bacteria only in mucosal samples (81.2%). Bacteroides intestinalis and Burkholderiales bacterium 1-1-47 in fecal samples were demmed important.
The excellent predictive power of microbiota may help in the diagnosis of difficult cases of CeD. The identification of important specific bacterial species that are reduced in CeD may have a potential protective role.
Future research in this area with larger sample sizes is needed to clarify the role of microbiota in the diagnosis and prevention of CeD.