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World J Gastroenterol. Mar 28, 2023; 29(12): 1852-1862
Published online Mar 28, 2023. doi: 10.3748/wjg.v29.i12.1852
Review of lymphoma in the duodenum: An update of diagnosis and management
Masaya Iwamuro, Takehiro Tanaka, Hiroyuki Okada
Masaya Iwamuro, Hiroyuki Okada, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan
Takehiro Tanaka, Department of Pathology, Okayama University Hospital, Okayama 700-8558, Japan
Author contributions: Iwamuro M designed the research study and wrote the paper; Tanaka T critically reviewed the manuscript for important intellectual content; Okada H approved the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masaya Iwamuro, MD, PhD, Assistant Professor, Doctor, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. pr145h2k@okayama-u.ac.jp
Received: December 5, 2022
Peer-review started: December 5, 2022
First decision: February 8, 2023
Revised: February 11, 2023
Accepted: March 14, 2023
Article in press: March 14, 2023
Published online: March 28, 2023
Processing time: 113 Days and 1.8 Hours
Core Tip

Core Tip: Among cases of primary duodenal lymphoma, follicular lymphoma was the most predominant, followed by diffuse large B-cell lymphoma, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma), mantle cell lymphoma, and T-cell lymphomas. A watch and wait policy is acceptable for follicular lymphoma. Observation without treatment is also an option for MALT lymphoma. However, it should be noted that duodenal MALT lymphoma has a higher rate of transformation to diffuse large B-cell lymphoma than gastric MALT lymphoma. Diffuse large B-cell lymphoma, mantle cell lymphoma, and T-cell lymphomas generally require systemic treatment.