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World J Gastroenterol. Jan 7, 2023; 29(1): 110-125
Published online Jan 7, 2023. doi: 10.3748/wjg.v29.i1.110
Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases
Evanthia Tourkochristou, Athanasia Mouzaki, Christos Triantos
Evanthia Tourkochristou, Christos Triantos, Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Patras, Patras 26504, Greece
Athanasia Mouzaki, Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras 26504, Greece
Author contributions: Triantos C conceived and coordinated the study; Tourkochristou E and Mouzaki A conducted the literature search and analysis and wrote the manuscript; Triantos C and Mouzaki A were responsible for revising the manuscript for important intellectual content; Tourkochristou E, Mouzaki A, and Triantos C approved the submitted version of the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with the senior author or any of the other coauthors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christos Triantos, FAASLD, MD, PhD, Assistant Professor, Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Patras, Rion, Patras 26504, Greece. chtriantos@hotmail.com
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: November 5, 2022
Revised: November 16, 2022
Accepted: December 13, 2022
Article in press: December 13, 2022
Published online: January 7, 2023
Core Tip

Core Tip: Recent literature has highlighted the use of novel oral small molecules, so-called sphingosine-1- phosphate (S1P) receptor modulators, in the therapeutic treatment of inflammatory bowel disease (IBD). Reviews and clinical trials have reported the safety profile and role of S1P modulators in alleviating IBD, but little information is available on their biological function. This is a comprehensive mini-review describing key biological mechanisms beyond the activity of S1P modulators reported in preclinical and clinical studies. The data from this study will contribute to the research field of developing therapeutic strategies in IBD based on the pathogenic biological background.