Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2022; 28(41): 5910-5930
Published online Nov 7, 2022. doi: 10.3748/wjg.v28.i41.5910
Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions
Yuan-Bin Liu, Ming-Kai Chen
Yuan-Bin Liu, Ming-Kai Chen, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430000, Hubei Province, China
Author contributions: Liu YB and Chen MK proposed the idea for the article; Liu YB carried out the literature search, wrote the manuscript, and prepared the language refinement; Chen MK revised the manuscript as the corresponding author and provided comments; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest in this study.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Kai Chen, MD, Chief Physician, Professor, Department of Gastroenterology, Renmin Hospital of WuHan University, No. 99 Zhang Zhidong Road, Wuhan 430000, Hubei Province, China. kaimingchen@163.com
Received: August 27, 2022
Peer-review started: August 27, 2022
First decision: September 25, 2022
Revised: September 30, 2022
Accepted: October 19, 2022
Article in press: October 19, 2022
Published online: November 7, 2022
Processing time: 68 Days and 22.1 Hours
Core Tip

Core Tip: The global burden of liver cirrhosis continues to rise. In 2017, there were 520000 new cases of cirrhosis and chronic liver disease. In 2019, cirrhosis caused 1.48 million deaths, an increase of 8.1% compared to 2017, and its disability-adjusted life-years ranked 16th among all diseases. The global burden of cirrhosis due to hepatitis B virus and hepatitis C virus infection is decreasing, while the burden of cirrhosis due to alcohol and nonalcoholic fatty liver disease is increasing rapidly. We also outlined the recent epidemiology of the major complications and hepatocellular carcinoma in cirrhosis.