Observational Study
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World J Gastroenterol. Oct 14, 2022; 28(38): 5636-5647
Published online Oct 14, 2022. doi: 10.3748/wjg.v28.i38.5636
Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease
Agata Michalak, Małgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz, Tomasz Lach, Halina Cichoż-Lach
Agata Michalak, Joanna Kozicka, Halina Cichoż-Lach, Department of Gastroenterology, Medical University of Lublin, Lublin 20-954, Poland
Małgorzata Guz, Marek Cybulski, Witold Jeleniewicz, Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin 20-093, Poland
Tomasz Lach, Department of Orthopedics and Traumatology, Medical University of Lublin, Lublin 20-954, Poland
Author contributions: Michalak A, Lach T and Cichoż-Lach H prepared data; Michalak A and Cichoż-Lach H invented and conducted the study; Guz M, Kozicka J and Jeleniewicz W applied the experiments, gained and interpreted data; Cybulski M statistically analyzed the data; Michalak A and Cichoż-Lach H wrote the article; All authors accepted the current version of the manuscript.
Institutional review board statement: The survey was accepted by the local ethics committee of the Medical University of Lublin (No. KE-0254/86/2016).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Halina Cichoż-Lach, PhD, Professor, Department of Gastroenterology, Medical University of Lublin, Jaczewski Str. 8, Lublin 20-954, Poland. lach.halina@wp.pl
Received: July 4, 2022
Peer-review started: July 4, 2022
First decision: July 31, 2022
Revised: August 7, 2022
Accepted: September 21, 2022
Article in press: September 21, 2022
Published online: October 14, 2022
Processing time: 99 Days and 7.5 Hours
Core Tip

Core Tip: Red blood cell distribution width (RDW), RDW-to-platelet ratio (RPR) and RDW-to-lymphocyte ratio (RLR) remain uninvestigated in Polish patients suffering from alcohol-related liver cirrhosis (ALC) and metabolic-associated liver disease. Based on the available literature, association between RDW, RPR, RLR and serological (indirect and direct) indices of liver fibrosis have never been explored in a single study to date. We consider RPR as a potential reliable diagnostic tool in the assessment of ALC patients, corresponding with MELD score and serous markers of liver cirrhosis. Hematological parameters could be perceived as possible indices in the noninvasive evaluation of people with liver disorders.