Review
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World J Gastroenterol. Oct 14, 2022; 28(38): 5515-5529
Published online Oct 14, 2022. doi: 10.3748/wjg.v28.i38.5515
Gastrointestinal and liver disease in patients with schizophrenia: A narrative review
Rebecca K Grant, William M Brindle, Mhairi C Donnelly, Pauline M McConville, Thomas G Stroud, Lorenzo Bandieri, John N Plevris
Rebecca K Grant, William M Brindle, Mhairi C Donnelly, John N Plevris, The Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
Pauline M McConville, Thomas G Stroud, Lorenzo Bandieri, General Adult Psychiatry, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, United Kingdom
Author contributions: Grant RK and Brindle WM conceived the study; Grant RK performed the literature review and drafted all sections of the manuscript except for the section on acute liver failure; Donnelly MC performed the literature review and drafted the section on acute liver failure; Brindle WM, Donnelly MC, McConville PM, Stroud TG, and Bandieri L critically revised the manuscript; Plevris JN was senior author and critically revised the manuscript for important intellectual content.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rebecca K Grant, BSc, MA, MBChB, MSc, The Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, 51 Little France Cres, Old Dalkeith Rd, Edinburgh, EH16 4SA, United Kingdom. rebecca.x.grant@nhs.scot
Received: July 18, 2022
Peer-review started: July 18, 2022
First decision: August 19, 2022
Revised: August 29, 2022
Accepted: September 21, 2022
Article in press: September 21, 2022
Published online: October 14, 2022
Processing time: 85 Days and 13.9 Hours
Core Tip

Core Tip: We report significant rates of liver disease, particularly Non-alcoholic Fatty Liver Disease, in patients with schizophrenia, in addition to emerging evidence regarding the prevalence of lower gastrointestinal disease and peptic ulcer disease. We have clearly demonstrated the importance of a multidisciplinary approach to management and propose recommendations to ameliorate future care of this vulnerable group of patients.