Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2022; 28(35): 5154-5174
Published online Sep 21, 2022. doi: 10.3748/wjg.v28.i35.5154
Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1
Fei-Fei Nong, Yu-Qi Liang, Shang-Ping Xing, Yin-Fang Xiao, Hui-Hui Chen, Bin Wen
Fei-Fei Nong, Yin-Fang Xiao, Hui-Hui Chen, Bin Wen, Pi-Wei Institute, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
Yu-Qi Liang, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
Shang-Ping Xing, Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, School of Pharmacy, Guangxi Medical University, Nanning 530022, Guangxi Zhuang Autonomous Region, China
Author contributions: Wen B designed the experiments; Nong FF and Liang YQ performed the experiments and wrote the paper; Xing SP revised the paper; Xiao YF and Chen HH analyzed the data; all authors have read and approved this final manuscript.
Supported by the National Natural Science Foundation of China, No. 81673944.
Institutional review board statement: All human subjects were approved by the Ethics Committee of The First Affiliated Hospital of Guangzhou University of Chinese Medicine [No. Y (2019) 172].
Institutional animal care and use committee statement: All animal protocols were approved by the Animal Care and Use Committee of the Guangzhou University of Chinese Medicine (Permit No. 20190801066).
Conflict-of-interest statement: The authors state that the study was conducted in the absence of any business or financial relationships that could be interpreted as potential conflicts of interest.
Data sharing statement: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Wen, PhD, Academic Research, Full Professor, Pi-Wei Institute, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, No. 232 Waihuandong Road, Guangzhou 510000, Guangdong Province, China. wenbin@gzucm.edu.cn
Received: May 25, 2022
Peer-review started: May 25, 2022
First decision: July 12, 2022
Revised: July 23, 2022
Accepted: August 22, 2022
Article in press: August 22, 2022
Published online: September 21, 2022
Processing time: 112 Days and 23.3 Hours
Core Tip

Core Tip: Our study indicated that alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer (CRC) by activating the early interaction between laminin-γ2 and integrin-β1 and lead to CRC metastasis.